지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.3
- 수록면
- 1 - 10 (10page)
- DOI
- 10.1016/j.afos.2022.03.001
이용수
초록· 키워드
오류제보하기
Cellular metabolism requires dissolved oxygen gas. Because evolutionary refinements have constrained mammalian dissolved oxygen levels, intracellular oxygen sensors are vital for optimizing the bioenergetic and biosynthetic use of dissolved oxygen. Prolyl hydroxylase domain (PHD) homologs 1-3 (PHD1/2/3) are molecular oxygen dependent non-heme dioxygenases whose enzymatic activity is regulated by the concentration of dissolved oxygen. PHD oxygen dependency has evolved into an important intracellular oxygen sensor. The most well studied mechanism of PHD oxygen-sensing is its regulation of the hypoxia-inducible factor (HIF) hypoxia signaling pathway. Heterodimeric HIF transcription factor activity is regulated post-translationally by selective PHD proline hydroxylation of its HIF1a subunit, accelerating HIF1a ubiquitination and proteasomal degradation, preventing HIF hetero dimer assembly, nuclear accumulation, and activation of its target oxygen homeostasis genes. Phd2 has been shown to be the key isoform responsible for HIF1a subunit regulation in many cell types and accordingly disruption of the Phd2 gene results in embryonic lethality. In bone cells Phd2 is expressed in high abundance and tightly regulated. Conditional disruption of the Phd1, Phd2 and/or Phd3 gene in various bone cell types using different Cre drivers reveals a major role for PHD2 in skeletal growth and development. In this review, we will summarize the state of current knowledge on the role and mechanism of action of PHD2 as oxygen sensor in regulating bone metabolism.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Prolyl hydroxylase-3 is a novel renal cell carcinoma biomarker
Investigative and Clinical Urology
2019 .01
-
Pleotropic effects of hypoxia-inducible factor-prolyl hydroxylase domain inhibitors: are they clinically relevant?
Kidney Research and Clinical Practice
2023 .01
-
Erratum : In Vitro Head-to-Head Comparison of Flow Reduction between Fibered and Non-Fibered Pushable Coils
Neurointervention
2024 .07
-
Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy
Yonsei Medical Journal
2017 .01
-
Hypoxia-Inducible Factor-1 Alpha Stabilization in Human Macrophages during Leishmania major Infection Is Impaired by Parasite Virulence
Parasites, Hosts and Diseases
2022 .10
-
Is Biochemical Follow Up Possible in Peripheral Arterial Disease Treatment: Hypoxia Inducible Factor-1 Alpha?
Vascular Specialist International
2021 .09
-
만성 신질환 환자에서 새로운 경구용 빈혈 치료제: Prolyl Hydroxylase Inhibitor
대한내과학회지
2019 .02
-
Hypoxia Induces Epithelial-Mesenchymal Transition in Follicular Thyroid Cancer: Involvement of Regulation of Twist by Hypoxia Inducible Factor-1α
Yonsei Medical Journal
2015 .01
-
치주건강상태에 따른 치간칫솔의 평균 PHD 비교연구
한국구강보건과학회지
2023 .06
-
저산소 조건에 의한 HepG2 세포주의 성장에서 HIF-1α 비의존적 기전의 확인
Journal of Liver Cancer
2016 .01
-
ACY-241, a histone deacetylase 6 inhibitor, suppresses the epithelial–mesenchymal transition in lung cancer cells by downregulating hypoxia-inducible factor-1 alpha
The Korean Journal of Physiology & Pharmacology
2024 .01
-
Efficacy of Oxygen Treatment Using Home Oxygen Concentrators for the Treatment of Cluster Headaches: A Randomized, Crossover, Multicenter Study
Journal of Clinical Neurology
2024 .01
-
Overexpression of CD44 Standard Isoform Upregulates HIF-1α Signaling in Hypoxic Breast Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Oxygen tank for synergistic hypoxia relief to enhance mitochondria-targeted photodynamic therapy
생체재료학회지
2022 .12
-
The effects of ventilation with high density oxygen on the strength of gastrointestinal anastomosis
Annals of Surgical Treatment and Research
2015 .06
-
mHealth의 활용을 통한 만성질환 예방 및 관리 가능성 모색
보건학논집
2016 .03
-
Current Situation of Home Oxygen Therapy for Chronic Obstructive Pulmonary Disease Patients in Korea
Journal of Korean Medical Science
2020 .01
-
네트워크 약리학 분석을 통한 황금의 바이러스성 폐렴 치료 기전 예측: HIF-1α와 HSP90 조절을 통한 저산소 상태 조절을 중심으로
대한한의학회지
2024 .06
-
Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/ SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
Journal of Breast Cancer
2018 .01
-
Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/ SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
Journal of Breast Cancer
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0