지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.5
- 수록면
- 476 - 485 (10page)
- DOI
- 10.4093/dmj.2021.0074
이용수
초록· 키워드
오류제보하기
Background: Creatinine-to-cystatin C ratio is recently suggested to be a surrogate marker for sarcopenia. However, little is known about its association with diabetes. This study aimed to fill in this gap based on a large-scale prospective cohort.Methods: A population-based representative sample of 5,055 participants aged ≥45 years from the China Health and Retirement Longitudinal Study was enrolled between 2011 and 2012 and followed at least once during the subsequent surveys at 2013, 2015, or 2018. Creatinine-to-cystatin C ratio was calculated and normalized by body weight. Incident diabetes was ascertained by plasma glucose, glycosylated hemoglobin, self-reported history, or use of anti-diabetic drugs. Logistic regression analysis and mediation analysis were employed.Results: During follow-up, 634 participants developed diabetes. The risk of diabetes was gradually and significantly decreased with increased normalized creatinine?cystatin C ratio. The multivariable-adjusted odds ratio for diabetes was 0.91 (95% confidence interval, 0.83 to 0.99) per 1 standard deviation higher of normalized creatinine-to-cystatin C ratio, and this relationship remained significant after controlling for muscle strength. The risk reduction in diabetes was significantly larger in participants with normal-weight and high normalized creatinine-to-cystatin C ratio compared with those with overweight/obesity and high normalized creatinine-to-cystatin C ratio (Pinteraction=0.01). Insulin resistance and inflammation appeared to be key mediators accounting for the observed relationship between normalized creatinine-to-cystatin C ratio and risk of diabetes, with their mediating effect being 93.1% and 22.0%, respectively.Conclusion: High normalized creatinine-to-cystatin C ratio is associated with reduced risk of diabetes in middle-aged and older adults.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Ratio of Estimated Glomerular Filtration Rate Based on Cystatin C and Creatinine Reflecting Cardiovascular Risk in Diabetic Patients
Diabetes and Metabolism Journal
2023 .05
-
Serum cystatin C to creatinine ratio is associated with sarcopenia in non-dialysis-dependent chronic kidney disease
Kidney Research and Clinical Practice
2022 .09
-
Cystatin C as a Predictor for Diabetes according to Glycosylated Hemoglobin Levels in Korean Patients
Diabetes and Metabolism Journal
2016 .01
-
Value of Serum Cystatin C Measurement in the Diagnosis of Sepsis-Induced Kidney Injury and Prediction of Renal Function Recovery
Yonsei Medical Journal
2017 .01
-
Exploring Renal Function Assessment: Creatinine, Cystatin C, and Estimated Glomerular Filtration Rate Focused on the European Kidney Function Consortium Equation
Annals of Laboratory Medicine
2024 .03
-
Cystatin C in pregnant women is not a simple kidney filtration marker
Kidney Research and Clinical Practice
2018 .01
-
Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients
Annals of Surgical Treatment and Research
2015 .04
-
Report of the Korean Association of External Quality Assessment Service on Accuracy-Based Creatinine Testing in Korea (2020–2021)
Journal of Laboratory Medicine And Quality Assurance
2022 .09
-
Molecular Characteristics and Potent Immunomodulatory Activity of Fasciola hepatica Cystatin
Parasites, Hosts and Diseases
2022 .04
-
Accuracy-Based Proficiency Testing of Creatinine Measurement: 7 Years’ Experience in Korea
Journal of Laboratory Medicine And Quality Assurance
2019 .01
-
Urinary Exosomal Cystatin C and Lipopolysaccharide Binding Protein as Biomarkers for Monitoring Antibody-mediated Rejection After Kidney Transplantation
대한외과학회 학술대회 초록집
2021 .11
-
추정 사구체여과율의 해석
대한내과학회지
2023 .02
-
The Relationship between Family History of Diabetes and Diabetes by BMI and Age in Korean Men and Women
대한의생명과학회지
2021 .12
-
Performances of serum creatinine, C-reactive protein and white blood cell to predict urinary tract infection in febrile children younger than 24 months of age
대한소아응급의학회지
2020 .01
-
Factors Associated with Participation in Diabetes Education: The Korea National Health and Nutrition Examination Survey 2007 to 2009
Diabetes and Metabolism Journal
2016 .01
-
화력발전소 영향권 주민 거주지의 이격 거리별 중금속 및 휘발성유기화합물 대사체 노출 농도 비교 분석
한국환경보건학회지
2024 .02
-
Estimating baseline creatinine values to define acute kidney injury in critically ill pediatric patients
Kidney Research and Clinical Practice
2022 .06
-
Association between Low Serum Creatinine Levels and Knee Osteoarthritis in Koreans without Renal Insufficiency
Yonsei Medical Journal
2024 .09
-
The Relationship between Renal Function and Bone Marrow Density in Healthy Korean Women
대한폐경학회지
2017 .08
-
Framingham Risk Score Assessment in Subjects with Pre-diabetes and Diabetes: A Cross-Sectional Study in Korea
Journal of Obesity & Metabolic Syndrome
2021 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0