Serum Biotin Levels in General Korean Population

문숙인; 조은혜; 박성준; 권민정; 박효순; 우희연

doi:10.47429/lmo.2022.12.3.191

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자료유형: 학술저널

저자정보: 문숙인 (성균관대학교 강북삼성병원 진단검사의학과) 조은혜 (성균관대학교 강북삼성병원 진단검사의학과) 박성준 (성균관대학교 강북삼성병원 진단검사의학과) 권민정 (성균관대학교 강북삼성병원 진단검사의학과) 박효순 (성균관대학교 강북삼성병원 진단검사의학과) 우희연 (성균관대학교 강북삼성병원 진단검사의학과)

저널정보: 대한진단검사의학회 Laboratory Medicine Online Laboratory Medicine Online 제12권 제3호

발행연도: 2022.7

수록면: 191 - 194 (4page)

DOI: 10.47429/lmo.2022.12.3.191

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The risk of biotin interference has been growing, as the intake of biotin for hair, skin, and nail care has increased. Elevated serum biotin concentra?tion can interfere with immunoassays, thereby possibly leading to serious medical problems. In this study, we estimated the risk of biotin interfer?ence by investigating the distribution of serum biotin concentration in the general population of Korea. From October 2020 to March 2021, 723 samples were collected from individuals (age: 18?81 years) who underwent a medical checkup. Biotin levels were quantified by liquid chromatog?raphy coupled with tandem mass spectrometry (LC-MS/MS). Biotin interference in the thyroid function test and vitamin D immunoassay was as?sessed for samples with biotin levels above 10 ng/mL. Thyroid function and vitamin D results obtained by a streptavidin-biotin-based electrochemi?luminescence immunoassay were compared to those of a chemiluminescent microparticle immunoassay and LC-MS/MS, respectively. A total of 0.41% (3/723) of samples showed serum biotin concentration above the lowest threshold (10 ng/mL) for biotin interference. Vitamin D status in a patient with serum biotin concentration of 130.3 ng/mL was normal according to the immunoassay (30.6 ng/mL) but deficient (29.3 ng/mL) ac?cording to LC-MS/MS. Judging by the distribution of biotin concentration in the general population, the risk of biotin interference seems to be low in Korea. Further studies are needed to monitor biotin concentration because biotin intake is increasing

#Biotin interference #Thyroid function test #Vitamin D

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