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논문 기본 정보

자료유형
학술저널
저자정보
Myeongsook Seo (Department of Gastroenterology Gangneung Asan Hospital University of Ulsan College of Medicine Gang) Jiyoung Yoon (Department of Gastroenterology Uijeongbu Eulji Medical Center Eulji University School of Medicine U) Kee Wook Jung (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K) Segyeong Joo (Departments of Biomedical Engineering Asan Medical Center University of Ulsan College of Medicine S) Jungbok Lee (Departments of Clinical Epidemiology and Biostatistics Asan Medical Center University of Ulsan Coll) Kyung Min Choi (Departments of Biomedical Engineering Asan Medical Center University of Ulsan College of Medicine S) Hyo Jeong Lee (Health Screening and Promotion Center Asan Medical Center University of Ulsan College of Medicine S) In Ja Yoon (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K) Woojoo Noh (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K) So Young Seo (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K) Do Yeon Kim (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K) Sung Wook Hwang (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K) Sang Hyoung Park (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K) Dong-Hoon Yang (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K) Byong Duk Ye (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K) Jeong-Sik Byeon (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K) Suk-Kyun Yang (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K) Seung-Jae Myung (Departments of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul K)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.28 No.4
발행연도
2022.10
수록면
608 - 617 (10page)
DOI
10.5056/jnm21137

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"Background/Aims Biofeedback therapy is widely used to treat patients with chronic constipation, especially those with dyssynergic defecation. Yet, the utility of high-resolution manometry with novel parameters in the prediction of biofeedback response has not been reported. Thus, we constructed a model for predicting biofeedback therapy responders by applying the concept of integrated pressurized volume in patients undergoing high-resolution anorectal manometry. Methods Seventy-one female patients (age: 48-68 years) with dyssynergic defecation who underwent initial high-resolution anorectal manometry and subsequent biofeedback therapy were enrolled. The manometry profiles were used to calculate the 3-dimensional integrated pressurized volumes by multiplying the distance, time, and amplitude during simulated evacuation. Partial least squares regression was performed to generate a predictive model for responders to biofeedback therapy by using the integrated pressurized volume parameters. Results Fifty-five (77.5%) patients responded to biofeedback therapy. The responders and non-responders did not show significant differences in the conventional manometric parameters. The partial least squares regression model used a linear combination of eight integrated pressurized volume parameters and generated an area under the curve of 0.84 (95% confidence interval: 0.76-0.95, P < 0.01), with 85.5% sensitivity and 62.1% specificity. Conclusions Integrated pressurized volume parameters were better than conventional parameters in predicting the responsiveness to biofeedback therapy, and the combination of these parameters and partial least squares regression was particularly promising. Integrated pressurized volume parameters can more effectively explain the physiology of the anorectal canal compared with conventional parameters."

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