The Clinical Impact of Advanced Age on the Postoperative Outcomes of Patients Undergoing Gastrectomy for Gastric Cancer: Analysis Across US Hospitals Between 2011–2017

Lee David Uihwan; Fan Gregory Hongyuan; Chang Kevin; Lee Ki Jung; Han John; Jung Daniel; Kwon Jean; Karagozian Raffi

doi:10.5230/jgc.2022.22.e18

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자료유형: 학술저널

저자정보: Lee David Uihwan (Division of Gastroenterology and Hepatology University of Maryland Baltimore MD USA.) Fan Gregory Hongyuan (Liver Center Division of Gastroenterology Tufts Medical Center Boston MA USA.) Chang Kevin (Liver Center Division of Gastroenterology Tufts Medical Center Boston MA USA.) Lee Ki Jung (Liver Center Division of Gastroenterology Tufts Medical Center Boston MA USA.) Han John (Liver Center Division of Gastroenterology Tufts Medical Center Boston MA USA.) Jung Daniel (Liver Center Division of Gastroenterology Tufts Medical Center Boston MA USA.) Kwon Jean (Liver Center Division of Gastroenterology Tufts Medical Center Boston MA USA.) Karagozian Raffi (Liver Center Division of Gastroenterology Tufts Medical Center Boston MA USA.)

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제22권 제3호

발행연도: 2022.7

수록면: 197 - 208 (12page)

DOI: 10.5230/jgc.2022.22.e18

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Purpose This study systematically evaluated the implications of advanced age on post-surgical outcomes following gastrectomy for gastric cancer using a national database. Materials and Methods The 2011–2017 National Inpatient Sample was used to isolate patients who underwent gastrectomy for gastric cancer. From this, the population was stratified into those belonging to the younger age cohort (18–59 years), sexagenarians, septuagenarians, and octogenarians. The younger cohort and each advanced age category were compared in terms of the following endpoints: mortality following surgery, length of hospital stay, charges, and surgical complications. Results This study included a total of 5,213 patients: 1,366 sexagenarians, 1,490 septuagenarians, 743 octogenarians, and 1,614 under 60 years of age. Between the younger cohort and sexagenarians, there was no difference in mortality (2.27 vs. 1.67%; P=0.30; odds ratio [OR], 1.36; 95% confidence interval [CI], 0.81–2.30), length of stay (11.0 vs. 11.1 days; P=0.86), or charges ($123,557 vs. $124,425; P=0.79). Compared to the younger cohort, septuagenarians had higher rates of in-hospital mortality (4.30% vs. 1.67%; P<0.01; OR, 2.64; 95% CI, 1.67–4.16), length of stay (12.1 vs. 11.1 days; P<0.01), and charges ($139,200 vs. $124,425; P<0.01). In the multivariate analysis, septuagenarians had higher mortality (P=0.01; adjusted odds ratio [aOR], 2.01; 95% CI, 1.18–3.43). Similarly, compared to the younger cohort, octogenarians had a higher rate of mortality (7.67% vs. 1.67%; P<0.001; OR, 4.88; 95% CI, 3.06–7.79), length of stay (12.3 vs. 11.1 days; P<0.01), and charges ($131,330 vs. $124,425; P<0.01). In the multivariate analysis, octogenarians had higher mortality (P<0.001; aOR, 4.03; 95% CI, 2.28–7.11).

#Aged #Gastric cancer #Gastrectomy #Elderly #Geriatric medicine

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