The Relationship of Steroid Hormones, Genes Related to Testosterone Metabolism and Behavior in Boys With Autism in Slovakia

Silvia Lakatošová; Katarína Janšáková; Jaroslava Babková; Gabriela Repiská; Ivan Belica; Mária Vidošovičová; Daniela Ostatníková

doi:10.30773/pi.2021.0094

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자료유형: 학술저널

저자정보: Silvia Lakatošová (Comenius University in Bratislava Faculty of Medicine Institute of Physiology) Katarína Janšáková (Comenius University in Bratislava Faculty of Medicine Institute of Physiology) Jaroslava Babková (Comenius University in Bratislava Faculty of Medicine Institute of Physiology) Gabriela Repiská (Comenius University in Bratislava Faculty of Medicine Institute of Physiology) Ivan Belica (Comenius University in Bratislava Faculty of Medicine Institute of Physiology) Mária Vidošovičová (Comenius University in Bratislava Faculty of Medicine Institute of Physiology) Daniela Ostatníková (Comenius University in Bratislava Faculty of Medicine Institute of Physiology)

저널정보: 대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제19권 제2호

발행연도: 2022.2

수록면: 73 - 84 (12page)

DOI: 10.30773/pi.2021.0094

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Objective Purpose of the study was to identify the relationship among actual plasmatic levels of steroid hormones and behavioral manifestations in boys with autism and to assess the genetic contribution to these manifestations.Methods 172 boys with autism under 10 years of age and 135 neurotypical boys attended the study. ADI-R and ADOS-2 were used to evaluate the core symptom severities. Problem behavior was assessed using BPI-01 questionnaire. Levels of testosterone, estradiol, dehydroepiandrosterone, dehydroepiandrosterone-sulfate and sex hormone binding globulin (SHBG) were measured in plasma of autistic boys. Three SNPs (in ESR1, SHBG, SRD5A2 genes) and one STR in AR gene (number of CAG repeats in first exon) were assessed. Hormonal levels and number of CAG repeats in AR gene were used for correlation analysis with behavioral measures. Genotype and allelic frequencies were compared among autistic and neurotypical boys.Results We found negative relationship among SHBG levels and restricted, repetitive behaviors (measured by ADOS-2) and positive relationship among actual testosterone levels and frequency of stereotyped behavior (measured by BPI-01).Conclusion Actual levels of SHBG and testosterone are related to severities of restricted and repetitive behaviors in boys with autism. Mechanisms of action of these hormones in brain require further investigation.

#Autism #Steroid hormones #Polymorphisms #Repetitive behavior.

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