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자료유형
학술저널
저자정보
Seo Young-Jun (Department of Pediatrics Hallym University Chuncheon Sacred Heart Hospital Chuncheon Korea) Kum Chang Dae (Department of Pediatrics Ajou University Hospital Ajou University School of Medicine Suwon Korea) Rho Jung Gi (Department of Pediatrics Ajou University Hospital Ajou University School of Medicine Suwon Korea) Shim Young Suk (Department of Pediatrics Ajou University Hospital Ajou University School of Medicine Suwon Korea) Lee Hae Sang (Department of Pediatrics Ajou University Hospital Ajou University School of Medicine Suwon Korea) Hwang Jin Soon (Department of Pediatrics Ajou University Hospital Ajou University School of Medicine Suwon Korea)
저널정보
대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatric Endocrinology & Metabolism 제27권 제2호
발행연도
2022.6
수록면
126 - 133 (8page)
DOI
10.6065/apem.2142174.087

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Purpose: We investigated the possible effects of diabetic ketoacidosis (DKA) at the initial diagnosis of type 1 diabetes mellitus (T1DM) on the clinical outcomes of pediatric patients.Methods: Medical records of children and adolescents with newly diagnosed T1DM seen in the Ajou University Hospital from January 2008 to August 2020 were reviewed and analyzed.Results: Among 129 diagnosed T1DM patients, 40.3% presented with DKA. Although demographic and basic characteristics did not differ between DKA and non-DKA patients, DKA patients needed a significantly higher insulin dosage than non-DKA patients for 2 years after diagnosis. However, control of glycated hemoglobin was not different between the DKA and non-DKA groups during the observation period. In the biochemical analysis, C-peptide, insulin-like growth factor-1, and insulin-like growth factor binding protein 3, high-density lipoprotein cholesterol, free T4, and T3 values were lower, but thyroid-stimulating hormone, initial serum glucose, uric acid, total cholesterol, triglyceride, and low-density lipoprotein cholesterol values were higher in DKA patients than non-DKA patients at the diagnosis of T1DM; however, these differences were temporarily present and disappeared with insulin treatment. Other clinical outcomes, such as height, thyroid function, and urine microalbumin level, did not vary significantly between the DKA and non-DKA groups during 5 years of follow-up.Conclusion: DKA at initial presentation reflects the severity of disease progression, and the deleterious effects of DKA seem to impact insulin secretion. Although no difference in long-term prognosis was found, early detection of T1DM should help to reduce DKA-related islet damage and the socioeconomic burden of T1DM.

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