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논문 기본 정보

자료유형
학술저널
저자정보
Fateme Sadat Najib (Department of Obstetrics and Gynecology School of Medicine Shiraz University of Medical Sciences) Tahereh Poordast (Shiraz University of Medical Science) Monireh Sufi Mahmudi (Department of Obstetrics and Gynecology School of Medicine Shiraz University of Medical Sciences) Zahra Shiravani (Shiraz University of Medical Sciences) Niloofar Namazi (Shiraz University of Medical Sciences) Gholamhossein Ranjbar Omrani (Endocrine and Metabolic Research Center Shiraz University of Medical Sciences)
저널정보
대한약침학회 Journal of Pharmacopuncture Journal of Pharmacopuncture 제25권 제2호
발행연도
2022.6
수록면
106 - 113 (8page)

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Objectives: Herbal medicine is a worldwide health topic. Vitex agnus–castus L. (VAC) is a popular plant used for gynecologic problems due to its hormonal effects. The aim of this study is to reveal VAC extract effect on fetus when this herb is used started from antenatal period or during pregnancy. Methods: Performed from starting day of January 2019 till February 2019, 48 rats were assigned in randomly divided eight-member six groups: control (C1), treated group with 365 mg/kg VAC from initiation of insemination (T1) and 30 days prior to pregnancy (T2), control that underwent caesarean section on 15 th day of gestational age (C2) and treated group with 365 mg/kg VAC from initiation of insemination (T3) and 30 days prior to pregnancy (T4) that underwent caesarean section. Weight, sex and number of fetuses, abortion and still birth rate and estradiol level were evaluated using t-test by SPSS software. Results: We showed increased weight among T1 group considering totally and sex-dependent which is significant (all p-value < 0.05). We also detected significantly decreased weight in T2 in total (p-value < 0.0001) and when considering female fetuses (0.043) but not males (0.17). Although the results showed slightly non-significant increased weight among fetuses of T3 (totally or based on the fetus sex) compared to the control group (C2), T4 group had statistically decreased weight compared to control group. Pregnancy rate and pregnancy outcome were affected by VAC usage. The time of VAC initiation also affected live birth and abortion rates. Conclusion: VAC extract may affect pregnancy rate, live birth rate, abortion and stillbirth rates. Its effect on the weight and the sex showed dual pattern depends on the time of initiation and pregnancy trimester of evaluation. Prescribing this medicinal plant for patients being prone to pregnancy should be with caution. Further study is recommended.

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