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논문 기본 정보

자료유형
학술저널
저자정보
Helena Abreu do Valle (Division of Gynaecologic Oncology Department of Gynaecology and Obstetrics University of British C) Paramdeep Kaur (Christian Medical College and Hospital) Janice S. Kwon (University of British Columbia and BC Cancer) Rona Cheifetz (Department of Surgery University of British Columbia Vancouver BC Canada) Lesa Dawson (Division of Gynaecologic Oncology Department of Gynaecology and Obstetrics University of British Co) Gillian E. Hanley (Division of Gynaecologic Oncology Department of Gynaecology and Obstetrics University of British Co)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.33 No.4
발행연도
2022.7
수록면
1 - 13 (13page)
DOI
https://doi.org/10.3802/jgo.2022.33.e51

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Objective: Examine the risks of fractures and osteoporosis after risk-reducing bilateral salpingo-oophorectomy (RRBSO) among women with mutations. Methods: In this retrospective population-based study in British Columbia, Canada, between 1996 to 2017, we compared risks of osteoporosis and fractures among women withmutations who underwent RRBSO before the age of 50 (n=329) with two age-matched groups without known mutations: 1) women who underwent bilateral oophorectomy (BO) (n=3,290); 2) women with intact ovaries who had hysterectomy or salpingectomy (n=3,290). Secondary outcomes were: having dual-energy X-ray absorptiometry (DEXA) scan, and bisphosphonates use. Results: The mean age at RRBSO was 42.4 years (range, 26?49) and the median follow-up for women with mutations was 6.9 years (range, 1.1?19.9). There was no increased hazard of fractures for women with mutations (adjusted hazard ratio [aHR]=0.80; 95% confidence interval [CI]=0.56?1.14 compared to women who had BO; aHR=1.02; 95% CI=0.65?1.61 compared to women with intact ovaries). Among women who had DEXA-scan, those with mutations had higher risk of osteoporosis (aHR=1.60; 95% CI=1.00?2.54 compared to women who had BO; aHR=2.49; 95% CI=1.44?4.28 compared to women with intact ovaries). Women with mutations were more likely to get DEXA-scan than either control groups, but only 46% of them were screened. Of the women withmutations diagnosed with osteoporosis, 36% received bisphosphonates. Conclusion: Women with mutations had higher risk of osteoporosis after RRBSO, but were not at increased risk of fractures during our follow-up. Low rates of DEXA-scan and bisphosphonates use indicate we can improve prevention of bone loss.

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