Modeling Survival in Patients With Brain Stroke in the Presence of Competing Risks

Norouzi Solmaz; Jafarabadi Mohammad Asghari; Shamshirgaran Seyed Morteza; Farzipoor Farshid; Fallah Ramazan

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자료유형: 학술저널

저자정보: Norouzi Solmaz (Faculty of Medicine Zanjan University of Medical Sciences Zanjan Iran) Jafarabadi Mohammad Asghari (Tabriz University of Medical Sciences Tabriz Iran) Shamshirgaran Seyed Morteza (Neyshabur University of Medical Sciences Neyshabur Iran) Farzipoor Farshid (Faculty of Health Tabriz University of Medical Sciences Tabriz Iran) Fallah Ramazan (Faculty of Medicine Zanjan University of Medical Sciences Zanjan Iran)

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제54권 제1호

발행연도: 2021.1

수록면: 55 - 62 (8page)

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Objectives: After heart disease, brain stroke (BS) is the second most common cause of death worldwide, underscoring the importance of understanding preventable and treatable risk factors for the outcomes of BS. This study aimed to model the survival of patients with BS in the presence of competing risks. Methods: This longitudinal study was conducted on 332 patients with a definitive diagnosis of BS. Demographic characteristics and risk factors were collected by a validated checklist. Patients’ mortality status was investigated by telephone follow-up to identify deaths that may be have been caused by stroke or other factors (heart disease, diabetes, high cholesterol, etc.). Data were analyzed by the Lunn-McNeil approach at alpha=0.1. Results: Older age at diagnosis (59-68 years: adjusted hazard ratio [aHR], 2.19; 90% confidence interval [CI], 1.38 to 3.48; 69-75 years: aHR, 5.04; 90% CI, 3.25 to 7.80; ≥76 years: aHR, 5.30; 90% CI, 3.40 to 8.44), having heart disease (aHR, 1.65; 90% CI, 1.23 to 2.23), oral contraceptive pill use (women only) (aHR, 0.44; 90% CI, 0.24 to 0.78) and ischemic stroke (aHR, 0.52; 90% CI, 0.36 to 0.74) were directly related to death from BS. Older age at diagnosis (59-68 years: aHR, 21.42; 90% CI, 3.52 to 130.39; 75-69 years: aHR, 16.48; 90% CI, 2.75 to 98.69; ≥76 years: aHR, 26.03; 90% CI, 4.06 to 166.93) and rural residence (aHR, 2.30; 90% CI, 1.15 to 4.60) were directly related to death from other causes. Significant risk factors were found for both causes of death. Conclusions: BS-specific and non-BS-specific mortality had different risk factors. These findings could be utilized to prescribe optimal and specific treatment.

#Stroke #Risk factors #Survival analysis #Models

참고문헌 (36)

참고문헌 신청

Feigin VL / 2017 / Global Burden of Stroke / Circ Res 120(3):439~448

Boehme AK / 2017 / Stroke risk factors, genetics, and prevention / Circ Res 120(3):472~495

Roger VL / 2011 / Heart disease and stroke statistics—2011 update: a report from the American Heart Association / Circulation 123(4):e18~e209

Ovbiagele B / 2013 / Forecasting the future of stroke in the United States : a policy statement from the American Heart Association and American Stroke Association / Stroke 44(8):2361~2375

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