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논문 기본 정보

자료유형
학술저널
저자정보
Young Jung Kim (Department of Internal Medicine Konkuk University School of Medicine Seoul Korea) Sun-Young Lee (Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea) Jeong Hwan Kim (Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea) In-Kyung Sung (Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea) Hyung Seok Park (Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea)
저널정보
대한소화기내시경학회 Clinical Endoscopy Clinical Endoscopy 제55권 제1호
발행연도
2022.1
수록면
67 - 76 (10page)
DOI
10.5946/ce.2020.299

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Background/Aims: Helicobacter pylori (H. pylori) seroconversion may occur during screening for gastric cancer. Our study aimed toassess the number of seroconverted subjects with H. pylori and their results in follow-up tests. Methods: Data were consecutively collected on subjects who were H. pylori-seronegative and presented for gastric cancer screening. Subjects who were followed up using the same serology test and pepsinogen (PG) assays on the day of endoscopy were included inthe study. Results: During the follow-up of 57.7±21.4 months, 61 (15.0%) of 407 seronegative subjects showed seroconversion. H. pyloriinfection was detected in six (9.8%) of 61 seroconverted subjects. A diffuse red fundal appearance, with a significant increase in theKyoto classification scores for gastritis, was observed in the infected subjects (p<0.001). Compared to the false-seropositive subjects,infected subjects showed higher serology titers (p<0.001) and PG II levels (p<0.001) and lower PG I/II ratios (p=0.002), in the followuptests. Conclusions: Seroconversion occurred in 3.3% of seronegative subjects per year; however, only 9.8% had H. pylori infection. Themajority (90.2%) of the seroconverted subjects showed false seropositivity without significant changes in the follow-up test results. The diffuse red fundal appearance could be an indicator of H. pylori infection.

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