메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Qi Dong (Department of Spine Surgery The Central Hospital Affiliated to Shaoxing University) Dan Zu (Central laboratory The Central Hospital Affiliated to Shaoxing University) Lingqiang Kong (Department of Spine Surgery The Central Hospital Affiliated to Shaoxing University) Sunfang Chen (Department of Spine Surgery The Central Hospital Affiliated to Shaoxing University) Jun Yao (Department of Spine Surgery The Central Hospital Affiliated to Shaoxing University) Jiawei Lin (Department of Spine Surgery The Central Hospital Affiliated to Shaoxing University) Lei Lu (Department of Spine Surgery The Central Hospital Affiliated to Shaoxing University) Bing Wu (Department of Spine Surgery The Central Hospital Affiliated to Shaoxing University) Bin Fang (Department of Spine Surgery The Central Hospital Affiliated to Shaoxing University)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제26권 제3호
발행연도
2022.9
수록면
606 - 623 (18page)
DOI
https://doi.org/10.1186/s40824-022-00281-7

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background: Hydrogels loaded with antimicrobial agents have been widely used for treating infected wound defects. However, hydrogels derived from a porcine dermal extracellular matrix (PADM), containing silver nanoparti cles (AgNPs), have not yet been studied. Therefore, we investigated the therapeutic effect of an AgNP-impregnated PADM (AgNP?PADM) hydrogel on the treatment of infected wounds. Methods: An AgNP?PADM hydrogel was synthesized by embedding AgNPs into a PADM hydrogel. We examined the porosity, moisture retention, degradation, antibacterial properties, cytotoxicity, antioxidant properties, and ability of the PADM and AgNP?PADM hydrogels to treat infected wounds in animals. Results: The PADM and AgNP?PADM hydrogels were pH sensitive, which made them flow dynamically and solidify under acidic and neutral conditions, respectively. The hydrogels also exhibited porous network structures, satisfac tory moisture retention, and slow degradation. Additionally, the AgNP?PADM hydrogel showed a slow and sustained release of AgNPs for at least 7 days without the particle size changing. Thus, the AgNPs exhibited adequate antibac terial ability, negligible toxicity, and antioxidant properties in vitro. Moreover, the AgNP?PADM hydrogel promoted angiogenesis and healed infected skin defects in vivo. Conclusions: The AgNP?PADM hydrogel is a promising bioderived antibacterial material for clinical application to infected wound dressings

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0