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논문 기본 정보

자료유형
학술저널
저자정보
Ka Shing Cheung (Department of Medicine Queen Mary Hospital) Lok Ka Lam (Department of Medicine Queen Mary Hospital) Rex Wan Hin Hui (Department of Medicine Queen Mary Hospital) Xianhua Mao (Department of Medicine Queen Mary Hospital) Ruiqi R Zhang (Department of Medicine Queen Mary Hospital) Kwok Hung Chan (Department of Microbiology The University of Hong Kong Queen Mary Hospital) Ivan FN Hung (Department of Medicine Queen Mary Hospital) Wai Kay Seto (Department of Medicine Queen Mary Hospital) Man-Fung Yuen (Department of Medicine Queen Mary Hospital)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제28권 제3호
발행연도
2022.7
수록면
553 - 564 (12page)
DOI
10.3350/cmh.2022.0082

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Background/Aims: Studies of hepatic steatosis (HS) effect on COVID-19 vaccine immunogenicity are lacking. We aimed to compare immunogenicity of BNT162b2 and CoronaVac among moderate/severe HS and control subjects. Methods: Two hundred ninety-five subjects who received BNT162b2 or CoronaVac vaccines from five vaccination centers were categorized into moderate/severe HS (controlled attenuation parameter ≥268 dB/m on transient elastography) (n=74) or control (n=221) groups. Primary outcomes were seroconversion rates of neutralising antibody by live virus Microneutralization (vMN) assay (titer ≥10) at day21 (BNT162b2) or day28 (CoronaVac) and day56 (both). Secondary outcome was highest-tier titer response (top 25% of vMN titer; cutoff: 160 [BNT162b2] and 20 [CoronaVac]) at day 56. Results: For BNT162b2 (n=228, 77.3%), there was no statistical differences in seroconversion rates (day21: 71.7% vs. 76.6%; day56: 100% vs. 100%) or vMN geometric mean titer (GMT) (day21: 13.2 vs. 13.3; day56: 91.9 vs. 101.4) among moderate/severe HS and control groups respectively. However, lower proportion of moderate/severe HS patients had highest-tier response (day56: 5.0% vs. 15.5%; P=0.037). For CoronaVac (n=67, 22.7%), there was no statistical differences in seroconversion rates (day21: 7.1% vs. 15.1%; day56: 64.3% vs. 83.0%) or vMN GMT (5.3 vs. 5.8,) at day28. However, moderate/severe HS patients had lower vMN GMT (9.1 vs. 14.8, P=0.021) at day 56 with lower proportion having highesttier response (21.4% vs. 52.8%, P=0.036). Conclusions: While there was no difference in seroconversion rate between moderate/severe HS and control groups after two doses of vaccine, a lower proportion of moderate/severe HS patients achieved highest-tier response for either BNT162b2 or CoronaVac.

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