High Cardiorespiratory Fitness Protects against Molecular Impairments of Metabolism, Heart, and Brain with Higher Efficacy in Obesity-Induced Premature Aging

Patcharapong Pantiya; Chanisa Thonusin; Natticha Sumneang; Benjamin Ongnok; Titikorn Chunchai; Sasiwan Kerdphoo; Thidarat Jaiwongkam; Busarin Arunsak; Natthaphat Siri-Angkul; Sirawit Sriwichaiin; Nipon Chattipakorn; Siriporn C. Chattipakorn

doi:https://doi.org/10.3803/EnM.2022.1430

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자료유형: 학술저널

저자정보: Patcharapong Pantiya (Chiang Mai University) Chanisa Thonusin (Chiang Mai University) Natticha Sumneang (Chiang Mai University) Benjamin Ongnok (Chiang Mai University) Titikorn Chunchai (Chiang Mai University) Sasiwan Kerdphoo (Chiang Mai University) Thidarat Jaiwongkam (Chiang Mai University) Busarin Arunsak (Chiang Mai University) Natthaphat Siri-Angkul (Chiang Mai University) Sirawit Sriwichaiin (Chiang Mai University) Nipon Chattipakorn (Chiang Mai University) Siriporn C. Chattipakorn (Chiang Mai University)

저널정보: 대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.37 No.4

발행연도: 2022.8

수록면: 630 - 640 (11page)

DOI: https://doi.org/10.3803/EnM.2022.1430

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Background: High cardiorespiratory fitness (CRF) protects against age-related diseases. However, the mechanisms mediating theprotective effect of high intrinsic CRF against metabolic, cardiac, and brain impairments in non-obese versus obese conditions remain incompletely understood. We aimed to identify the mechanisms through which high intrinsic CRF protects against metabolic,cardiac, and brain impairments in non-obese versus obese untrained rats. Methods: Seven-week-old male Wistar rats were divided into two groups (n=8 per group) to receive either a normal diet or a highfat diet (HFD). At weeks 12 and 28, CRF, carbohydrate and fatty acid oxidation, cardiac function, and metabolic parameters wereevaluated. At week 28, behavior tests were performed. At the end of week 28, rats were euthanized to collect heart and brain samplesfor molecular studies. Results: The obese rats exhibited higher values for aging-related parameters than the non-obese rats, indicating that they experienced obesity-induced premature aging. High baseline CRF levels were positively correlated with several favorable metabolic, cardiac, and brain parameters at follow-up. Specifically, the protective effects of high CRF against metabolic, cardiac, and brain impairments were mediated by the modulation of body weight and composition, the lipid profile, substrate oxidation, mitochondrial function, insulin signaling, autophagy, apoptosis, inflammation, oxidative stress, cardiac function, neurogenesis, blood-brain barrier, synaptic function, accumulation of Alzheimer’s disease-related proteins, and cognition. Interestingly, this effect was more obvious inHFD-fed rats. Conclusion: The protective effect of high CRF is mediated by the modulation of several mechanisms. These effects exhibit greaterefficacy under conditions of obesity-induced premature aging.

#Cardiorespiratory fitness #Metabolic syndrome #Cardiovascular diseases #Neurodegenerative diseases #Obesity #Aging #premature

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