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논문 기본 정보

자료유형
학술저널
저자정보
손형은 (중앙대학교) 류지영 (분당서울대학교병원) 이경훈 (분당서울대학교병원) 최영일 (아주대학교) 김명성 (아주대학교) 박인휘 (아주대학교) 신규태 (아주대학교) 김흥수 (아주대학교) 안규리 (서울대학교) 김세중 (분당서울대학교병원) 진호준 (서울대학교) 나기영 (서울대학교) 채동완 (서울대학교) 안소연 (분당서울대학교병원) 황승식 (서울대학교) 정종철 (분당서울대학교병원)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.41 No.5
발행연도
2022.9
수록면
611 - 622 (12page)
DOI
10.23876/j.krcp.21.153

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Background: Patients undergoing hemodialysis are susceptible to sarcopenia. As intracellular reservoirs of water, skeletal muscles are important contributors to intradialytic hypotension. This study was designed to determine the role of skeletal muscle mass in intradialytic hypotension. Methods: In a cross-sectional study, the body composition of 177 patients was measured immediately after hemodialysis using bioelectrical impedance analysis. The parameters measured were skeletal muscle mass, intracellular and extracellular water contents, total body water, and cell-membrane functionality (in phase angle at 50 kHz). Data from laboratory tests, chest radiography, measurements of handgrip strength and mid-arm circumference, and questionnaires were collected. The main outcome was intradialytic hypotension, defined as more than two episodes of hypotension (systolic blood pressure of <90 mmHg) with intervention over the 3 months following enrollment. Logistic regression models including each parameter related to sarcopenia were compared with a clinical model. Results: Patients with a low ratio of skeletal muscle mass to dry body weight (SMM/WT) had a higher rate of intradialytic hypotension (40.7%). Most low-SMM/WT patients were female, obese, diabetic, and had a lower handgrip strength compared with the other patients. In the high-SMM/WT group, the risk of intradialytic hypotension was lower, with an odds ratio of 0.08 (95% confidence interval [CI], 0.02–0.28) and adjusted odds ratio of 0.06 (95% CI, 0.01–0.29). Conclusion: Measurement and maintenance of skeletal muscle can help prevent intradialytic hypotension in frail patients undergoing hemodialysis.

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