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학술저널
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정원기 (전남대학교) 김윤현 (전남대학교) 이종은 (전남대학교병원) 오인재 (전남대학교) 송상윤 (전남대학교) 채금주 (전북대학교병원) 박혜미 (전남대학교)
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제54권 제3호
발행연도
2022.7
수록면
744 - 752 (9page)
DOI
10.4143/crt.2021.772

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PurposeIdentifying pretreatment interstitial lung abnormalities (ILAs) is important because of their predictive value for complications after lung cancer treatment. This study aimed to assess the predictive value of ILAs for postoperative pulmonary complications (PPCs) in elderly patients undergoing curative resection for early-stage non-small cell lung cancer (NSCLC).Materials and MethodsElderly patients (age ≥ 70 years) who underwent curative resection for pathologic stage I or II NSCLC with normal preoperative spirometry results (pre-bronchodilator forced expiratory volume in 1 s to forced vital capacity [FVC] ratio > 0.70 and FVC ≥ 80% of the predicted value) between January 2012 and December 2019 were retrospectively identified. Univariable and multivariable regression analyses were performed to assess risk factors for PPCs. The Kaplan?Meier method and log-rank test were used to analyze the relationship between ILAs and postoperative mortality. One-way analysis of variance was performed to assess the correlation between ILAs and hospital stay duration.ResultsA total of 262 patients (median age, 73 [interquartile range, 71?76] years; 132 male) were evaluated. A multivariable logistic regression model revealed that, among several relevant risk factors, fibrotic ILAs independently predicted both overall PPCs (adjusted odds ratio [OR], 4.84; 95% confidence interval [CI], 1.35?17.38; p=0.016) and major PPCs (adjusted OR, 8.72; 95% CI, 1.71?44.38; p=0.009). Fibrotic ILAs were significantly associated with higher postoperative mortality and longer hospital stay (F=5.21, p=0.006).ConclusionPretreatment fibrotic ILAs are associated with PPCs, higher postoperative mortality, and longer hospital stay.

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