지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.2
- 수록면
- 187 - 194 (8page)
- DOI
- 10.3349/ymj.2022.63.2.187
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초록· 키워드
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Purpose: A pilot project using epinephrine at the scene under medical control is currently underway in Korea. This study aimedto determine whether prehospital epinephrine administration is associated with improved survival and neurological outcomesin out-of-hospital cardiac arrest (OHCA) patients who received epinephrine during cardiopulmonary resuscitation (CPR) in theemergency department.
Materials and Methods: This retrospective observational study used a nationwide multicenter OHCA registry. Patients were classifiedinto two groups according to whether they received epinephrine at the scene or not. The associations between prehospitalepinephrine use and outcomes were assessed using propensity score (PS)-matched analysis. Multivariable logistic regression analysiswas performed using PS matching. The same analysis was repeated for the subgroup of patients with non-shockable rhythm.
Results: PS matching was performed for 1084 patients in each group. Survival to discharge was significantly decreased in the patientswho received prehospital epinephrine [odds ratio (OR) 0.415, 95% confidence interval (CI) 0.250–0.670, p<0.001]. However,no statistical significance was observed for good neurological outcome (OR 0.548, 95% CI 0.258–1.123, p=0.105). For the patientsubgroup with non-shockable rhythm, prehospital epinephrine was also associated with lower survival to discharge (OR 0.514, 95%CI 0.306–0.844, p=0.010), but not with neurological outcome (OR 0.709, 95% CI 0.323–1.529, p=0.382).
Conclusion: Prehospital epinephrine administration was associated with decreased survival rates in OHCA patients but not statisticallyassociated with neurological outcome in this PS-matched analysis. Further research is required to investigate the reasonfor the detrimental effect of epinephrine administered at the scene.
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