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논문 기본 정보

자료유형
학술저널
저자정보
Hwang Jae Kyoon (Department of Pediatrics Hanyang University Guri Hospital Guri Korea.) Kang Ha-Na (Department of Pediatrics Cheongju St. Mary’s Hospital Cheongju Korea.) Ahn Ja-Hye (Department of Pediatrics Hanyang University Seoul Hospital Seoul Korea.) Hyun Ju Lee (Department of Pediatrics Hanyang University Seoul Hospital Seoul Korea) Hyun-Kyung Park (Department of Pediatrics Hanyang University Seoul Hospital Seoul Korea) Chang-Ryul Kim (Department of Pediatrics Hanyang University Guri Hospital Guri Korea)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.24
발행연도
2022.6
수록면
1 - 13 (13page)
DOI
10.3346/jkms.2022.37.e198

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Background: To evaluate how intrauterine stress affects extremely premature infants in terms of intrauterine growth restriction. We hypothesized that extremely premature infants with mildly-low ponderal index (MPI) would have better neonatal outcomes. Methods: We selected 2,721 subjects of 23 to 28 weeks of gestation between 2013 and 2015 from Korean Neonatal Network database. They were divided into 4 groups based on ponderal index (PI) percentile; PI ≤ 3rd as severely-low PI (SPI, n = 82), 3rd < PI ≤ 10th as MPI (n = 190), 10th < PI ≤ 90th as adequate PI (API, n = 2,179), and PI > 90th as high PI (HPI, n = 270). Results: The mortality in MPI and API groups was comparable (16.3% vs. 16.9%). It was significantly lower than that in the SPI and HPI groups (30.5% and 24.9%, respectively; P = 0.001). The MPI and API groups had better neonatal morbidities compared with the SPI and/or HPI groups, while the MPI group (8.2%) showed a lower incidence of severe intraventricular hemorrhage (IVH) than the other groups (SPI, 21.3%; API, 15.0%; HPI, 19.7%, respectively; P = 0.004). The MPI group had a trend of a bottom in neonatal mortality and morbidities in extremely premature infants. Conclusion: The MPI and API groups had lower mortality, massive pulmonary hemorrhage, severe bronchopulmonary dysplasia or death, pulmonary hypertension and neonatal seizure rates than the SPI and/or HPI groups, while the MPI group showed a lower incidence of severe IVH than the other groups. We speculate that the lower incidence of neonatal morbidities and mortality in the MPI group indicating mild intrauterine stress might accelerate fetal maturation resulting in better outcomes in extremely premature infants.

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