지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.4
- 수록면
- 1 - 10 (10page)
- DOI
- 10.3346/jkms.2022.37.e68
이용수
초록· 키워드
오류제보하기
Background: Denosumab (DEN) and zoledronic acid (ZOL) currently represent the most potent antiresorptive agents for the treatment of osteoporosis. Despite similar effects on bone resorption, these agents have distinct mechanisms of action. The objective of this study was to compare the effect of DEN and ZOL after two-year administration on bone mineral density (BMD), trabecular bone score (TBS), bone turnover markers, and persistence.
Methods: A total of 585 postmenopausal women with osteoporosis who did not use osteoporosis medications were retrospectively reviewed. 290 patients were administered 60 mg DEN subcutaneously every 6 months from 2017 to 2018, and 295 patients were treated with 5 mg ZOL intravenously yearly from 2015 to 2017. BMD, TBS, and C-terminal crosslinking telopeptide of type 1 collagen (CTX) measurements were obtained at baseline and two-year after DEN injection or ZOL infusion.
Results: After two-year follow-up, 188 patients in the DEN group and 183 patients in the ZOL group were compared. BMD change from baseline at two years was significantly greater in the DEN group compared with the ZOL group (P < 0.001). The changes of TBS in the DEN group were statistically significant compared with baseline (P < 0.001) and the ZOL group (P < 0.001). The DEN group led to significantly greater reduction of CTX compared with ZOL group (P = 0.041).
Conclusion: In postmenopausal women with osteoporosis, DEN was associated with greater BMD increase at all measured skeletal sites, greater increase of TBS, and greater inhibition of bone remodeling compared with ZOL.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Two-year effectiveness of zoledronic acid with or without eldecalcitol in Japanese patients with osteoporosis: A randomized prospective study
Osteoporosis and Sarcopenia
2022 .06
-
Longitudinal Change in Trabecular Bone Score during and after Treatment of Osteoporosis in Postmenopausal Korean Women
대한골대사학회지
2017 .01
-
Associations between bone mineral density, trabecular bone score, and body mass index in postmenopausal females
Osteoporosis and Sarcopenia
2020 .01
-
The Changes of CTX, DPD, Osteocalcin, and Bone Mineral Density During the Postmenopausal Period
Annals of Rehabilitation Medicine
2018 .01
-
Application of the Trabecular Bone Score in Clinical Practice
대한골대사학회지
2021 .01
-
Bone microarchitecture and bone mineral density in Graves’ disease
Osteoporosis and Sarcopenia
2023 .06
-
Effect of Romosozumab on Trabecular Bone Score Compared to Anti-Resorptive Agents in Postmenopausal Women with Osteoporosis
대한골대사학회지
2021 .11
-
Compliance and discontinuation of denosumab treatment in postmenopausal Japanese women with primary osteoporosis or rheumatoid arthritis and osteoporosis
Osteoporosis and Sarcopenia
2017 .01
-
Bone Mineral Density, Trabecular Bone Score and Fractures in Patients Hospitalized for Heart Failure
대한골대사학회지
2023 .05
-
The correlation between bone mineral density/trabecular bone score and body mass index, height, and weight
Osteoporosis and Sarcopenia
2017 .01
-
The Vietnam Osteoporosis Study: Rationale and design
Osteoporosis and Sarcopenia
2017 .01
-
Clinical Factors Associated With Trabecular Bone Score in Koreans: A Retrospective Study
Annals of geriatric medicine and research
2016 .01
-
New Antiresorptive Therapies for Postmenopausal Osteoporosis
대한폐경학회지
2015 .01
-
Assessment of Denosumab in Korean Postmenopausal Women with Osteoporosis: Randomized, Double-Blind, Placebo-Controlled Trial with Open-Label Extension
Yonsei Medical Journal
2016 .01
-
골다공증의 약물치료: 2022 update
대한의사협회지
2022 .04
-
Three-dimensional microstructure of human alveolar trabecular bone: a micro-computed tomography study
Journal of Periodontal & Implant Science
2017 .01
-
Changes in Bone Metabolism in Young Castrated Male Rats
Yonsei Medical Journal
2016 .01
-
Validation of the Thai Osteoporosis Foundation and Royal College of Orthopaedic Surgeons of Thailand Clinical Practice Guideline for bone mineral density measurement in postmenopausal women
Osteoporosis and Sarcopenia
2015 .01
-
The Effects of Low-Dose Bisphosphonate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Patients With Osteoporosis
Annals of geriatric medicine and research
2016 .01
-
Low bone mineral density in children and adolescents with cancer
Annals of Pediatirc Endocrinology & Metabolism
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0