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논문 기본 정보

자료유형
학술저널
저자정보
Wonyoung Jung (Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine,) Jiyoung Kim (Department of Family Medicine, Seoul National University Hospital, Seoul, Korea) In Young Cho (Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) Keun Hye Jeon Yun-Mi Song (Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine,)
저널정보
대한가정의학회 Korean Journal of Family Medicine Korean Journal of Family Medicine 제43권 제5호
발행연도
2022.9
수록면
334 - 343 (10page)
DOI
10.4082/kjfm.21.0148

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Background: Hearing loss (HL) has been suggested to be associated with impaired microcirculation of the inner ear. This cross-sectional study aimed to evaluate an association between HL and serum lipid levels.Methods: The study comprised 10,356 Korean adults who participated in the fifth Korea National Health and Nutri-tion Examination Survey (2010?2012). We defined HL as the average hearing thresholds exceeding 25 dB at prede-termined frequency levels by pure tone audiometry. Serum lipid levels were measured using an enzymatic assay. The associations between lipid levels and HL were evaluated using a multiple logistic regression model after ad-justing for covariates including age, sex, hypertension, diabetes, smoking status, alcohol, physical activity, educa-tional level, household income, and noise exposure. Stratified analyses were performed to examine the effect of the covariates on the association between lipid levels and HL.Results: The high-density lipoprotein cholesterol (HDL-C) level was inversely associated with high-frequency (HF)-HL, with an odds ratio (95% confidence interval) of 0.78 (0.64?0.96) for 1-mmol/L increase in the HDL-C lev-el. Neither the triglyceride nor the low-density lipoprotein cholesterol level was associated with HF-HL. For low-frequency HL, association with any of the serum lipid components was absent. A stratified analysis showed that the inverse association between HDL-C levels and HF-HL was evident (P trend <0.05) in some subjects with specific characteristics such as older age (≥65 years), female sex, non-hypertensive state, and non-regular physical activity. However, a significant interaction between HDL-C levels and all of the stratified variables was absent (P for interac-tion >0.05).Conclusion: The HDL-C level has a linear inverse association with the risk of HF-HL. Given the known protective role of HDL-C against atherosclerotic changes, this finding seems to support the concept of impaired microcircula-tion in the inner ear as a mechanism for HF-HL.

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