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논문 기본 정보

자료유형
학술저널
저자정보
Jae-woo Lee (Department of Family Medicine, Chungbuk National University Hospital, Cheongju, Korea) Woojung Yang (Department of Family Medicine, Chungbuk National University Hospital, Cheongju, Korea) Ye-Seul Kim (Department of Family Medicine, Chungbuk National University Hospital, Cheongju, Korea) Yonghwan Kim (Department of Family Medicine, Chungbuk National University Hospital, Cheongju, Korea) Hyo-Sun Yoo (Department of Family Medicine, Chungbuk National University Hospital, Cheongju, Korea) Hee-Taik Kang (Department of Family Medicine, Chungbuk National University Hospital, Cheongju, Korea)
저널정보
대한가정의학회 Korean Journal of Family Medicine Korean Journal of Family Medicine 제43권 제2호
발행연도
2022.3
수록면
117 - 124 (8page)

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Background: The International Agency for Research on Cancer classifies 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) as a known carcinogen. This study aimed to investigate the association between exposure to secondhand smoke (SHS) and NNAL concentrations in non-smokers.Methods: This was a cross-sectional study based on data from the 2016 to 2018 Korea National Health and Nutri-tion Examination Survey. Urine NNAL concentrations were categorized into tertiles of 3,615 study participants who were non-smokers. All sampling and weight variables were stratified, and analyses to account for the complex sam-pling design were conducted.Results: The overall, male, and female percentages of SHS exposure among non-smokers were 22.4%, 29.2%, and 20.4%, respectively. The geometric means of urine NNAL concentrations were 1.896±0.098 pg/mL and 1.094±0.028 pg/mL in the SHS exposure and non-exposure groups, respectively. After adjusting for confounding variables, in the total group, the geometric mean of urine NNAL concentrations was significantly higher in the SHS exposure group than in the SHS non-exposure group (adjusted P-value <0.001). Compared with the non-exposure group, the adjusted odds ratios (95% confidence intervals) for the highest NNAL tertile group of overall SHS exposure in the total, men, and women groups were 2.44 (1.95?3.05), 1.65 (1.08?2.53), and 2.73 (2.11?3.52), respectively, after full adjustment.Conclusion: The urine NNAL concentration in the SHS exposure group was significantly higher than that in the non-exposure group. Exposure to SHS was associated with a higher risk of elevated urine NNAL concentrations in non-smokers.

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