Special AT-rich sequence-binding protein 2 (SATB2) in the differential diagnosis of osteogenic and non-osteogenic bone and soft tissue tumors

Sharon Milton; Anne Jennifer Prabhu; V. T. K. Titus; Rikki John; Selvamani Backianathan; Vrisha Madhuri

doi:10.4132/jptm.2022.07.11

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자료유형: 학술저널

저자정보: Sharon Milton (Christian Medical College Vellore) Anne Jennifer Prabhu (Christian Medical College Vellore) V. T. K. Titus (Christian Medical College Vellore) Rikki John (Christian Medical College Vellore) Selvamani Backianathan (Christian Medical College Vellore) Vrisha Madhuri (Christian Medical College Vellore)

저널정보: 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제56권 제5호

발행연도: 2022.9

수록면: 270 - 280 (11page)

DOI: 10.4132/jptm.2022.07.11

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Background: The diagnosis of osteosarcoma (OSA) depends on clinicopathological and radiological correlation. A biopsy is considered the gold standard for OSA diagnosis. However, since OSA is a great histological mimicker, diagnostic challenges exist. Immunohistochemistry (IHC) can serve as an adjunct for the histological diagnosis of OSA. Special AT-rich sequence-binding protein 2 (SATB2) was recently described as a reliable adjunct immunohistochemical marker for the diagnosis of OSA.Methods: We investigated the IHC expression of SATB2 in 95 OSA and 100 non-osteogenic bone and soft tissue tumors using a monoclonal antibody (clone EPNCIR30A). The diagnostic utility of SATB2 and correlation with clinicopathological parameters were analyzed.Results: SATB2 IHC was positive in 88 out of 95 cases (92.6%) of OSA and 50 out of 100 cases (50.0%) of primary non-osteogenic bone and soft tissue tumors. Of the 59 bone tumors, 37 cases (62.7%) were positive for SATB2, and of the 41 soft tissue tumors, 13 cases (31.7%) were positive for SATB2. The sensitivity of SATB2 as a diagnostic test was 92.6%, specificity 50%, positive predictive value 63.8%, and negative predictive value 87.7%.Conclusions: Although SATB2 is a useful diagnostic marker for OSA, other clinical, histological and immunohistochemical features should be considered for the interpretation of SATB2.

#SATB2 protein #Osteosarcoma #Immunohistochemistry #Osteoid #Non-osteogenic

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