지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.9
- 수록면
- 590 - 596 (7page)
- DOI
- 10.3343/alm.2022.42.5.590
이용수
초록· 키워드
오류제보하기
The translocation (3;21)(q26.2;q22.1) is a unique cytogenetic aberration that characterizes acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) in patients with AML and myelodysplastic syndrome (MDS) or a therapy-related myeloid neoplasm. Using multigene target sequencing and FISH, we investigated the clinical and genomic profiles of patients with t(3;21) over the past 10 years. The frequency of t(3;21) among myeloid malignancies was very low (0.2%). Half of the patients had a history of cancer treatment and the remaining patients had de novo MDS. Twenty-one somatic variants were detected in patients with t(3;21), including in CBL, GATA2, and SF3B1. Recurrent variants in RUNX1 (c.1184A>C, p.Glu395Ala) at the same site were detected in two patients. None of the patients with t(3;21) harbored germline predisposition mutations for myeloid neoplasms. MECOM rearrangement was detected at a higher rate using FISH than using G-banding, suggesting that FISH is preferable for monitoring. Although survival of patients with t(3;21) is reportedly poor, the survival of patients with t(3;21) in this study was not poor when compared with that of other AML patients in Korea.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
급성골수성백혈병과 골수이형성증후군 환자를 대상으로 한 NGS 골수성 패널 검사: 단일 상급종합병원에서의 경험
Laboratory Medicine Online
2021 .01
-
The First Case of Acute Myeloid Leukemia With a Novel Five-way Variant Translocation of RUNX1–RUNX1T1
Annals of Laboratory Medicine
2023 .05
-
LSAMP Rearrangement in Acute Myeloid Leukemia With a Jumping Translocation Involving 3q13.31
Annals of Laboratory Medicine
2021 .01
-
Rare Gene Rearrangement t(11;22)(q23;q13)/ KMT2A-EP300 in Therapy-related Acute Myeloid Leukemia: A Case Report
Annals of Laboratory Medicine
2022 .11
-
3방향전위 t(3;21;8)(p21;q22;q22)와 2방향전위 t(2;11)(q31;p15)의 2가지 염색체 이상이 동시에 관찰된 급성골수성백혈병 1예
Laboratory Medicine Online
2016 .01
-
A Novel Germline Mutation in DDX41 Predisposed to Myelodysplasia/Acute Myeloid Leukemia
Laboratory Medicine Online
2022 .07
-
Rare Incidence of ROS1 Rearrangement in Cholangiocarcinoma
Cancer Research and Treatment
2017 .01
-
First Case of Double T-Cell Receptor Alpha/Delta Rearrangements of t(11;14) and inv(14) and Subsequent JAK2 Rearrangement in a Patient With T-cell Acute Lymphoblastic Leukemia
Annals of Laboratory Medicine
2020 .01
-
Acute Myeloid Leukemia: Clinical Spectrum of 125 Patients
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Clinical Features of Lung Cancer in Japanese Patients Aged Under 50
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Myelodysplastic syndrome with genetic predisposition
Blood Research
2021 .01
-
Myelodysplastic syndrome with genetic predisposition
Blood Research
2021 .04
-
Establishment and operation of a cooperative program to identify work-related acute myeloid leukemia in a general hospital
대한직업환경의학회지
2019 .12
-
포커스 그룹 인터뷰를 이용한 환자안전전담자의 환자 및 보호자 대상 환자 안전 교육 경험 분석
한국의료질향상학회지
2019 .01
-
방사선 치료 시 환자 Set-up Line 개선을 통한 암환자 삶의 질 만족도 향상
대한방사선치료학회지
2018 .01
-
Education for Cancer Patient
대한임상종양학회 학술대회지
2015 .02
-
Education for Cancer Patients
대한임상종양학회 학술대회지
2015 .02
-
의원급 의료기관 환자의 환자경험과 환자안전인식의 관계에서 환자안전지식의 조절효과
성인간호학회지
2021 .08
-
Primary malignant mucosal melanoma of the maxillofacial area
대한구강악안면외과학회지
2021 .04
-
Clinicopathological features of Xp11.2 translocation renal cell carcinoma
Investigative and Clinical Urology
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0