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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.10
- 수록면
- 319 - 329 (11page)
- DOI
- 10.7783/KJMCS.2022.30.5.319
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초록· 키워드
오류제보하기
Background: The anti-inflammatory effect of Chrysanthmi Flos (CF), primarily produced in the wild and recently being cultivated in Korea was investigated for using it as an anti-inflammatory material.
Methods and Results: For measuring anti-inflammatory activity, CF was freeze-dried (CFEFD) after water extraction. The production of nitric oxide (NO), prostaglandin E₂ (PGE₂) and proinflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6] via ELISA, and expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), c-Jun Nterminal kinase (JNK)1/2, extracellular-signal-regulated kinase (ERK)1/2, p38, phosphorylated inhibitor of the transcriptional factor NF-κB (IκBα), p65 (a subunit of nuclear factor-κB) protein were determined using Western blot. The production of NO, PGE₂, TNF-α, IL-1β, and IL-6 reduced in a concentration-dependent manner by CFEFD treatment (100 ㎍/㎖ - 400 ㎍/㎖) than that by lipopolysaccharide treatment. iNOS and COX-2 protein expressions were inhibited at a concentration of 100 ㎍/㎖ - 400 ㎍/㎖ and 100 ㎍/㎖ - 200 ㎍/㎖, respectively, by the CFEFD treatment. JNK1/2, ERK1/2, p38 and phosphorylated IκBα protein expressions were inhibited in a concentration-dependent manner by the CFEFD treatment. The expression of p65 protein increased in the cytoplasm and was inhibited in the cell nucleus in a concentration-dependent manner.
Conclusions: Water extract of CF exhibited high anti-inflammatory activity, thus having high value as an anti-inflammatory material.
Methods and Results: For measuring anti-inflammatory activity, CF was freeze-dried (CFEFD) after water extraction. The production of nitric oxide (NO), prostaglandin E₂ (PGE₂) and proinflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6] via ELISA, and expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), c-Jun Nterminal kinase (JNK)1/2, extracellular-signal-regulated kinase (ERK)1/2, p38, phosphorylated inhibitor of the transcriptional factor NF-κB (IκBα), p65 (a subunit of nuclear factor-κB) protein were determined using Western blot. The production of NO, PGE₂, TNF-α, IL-1β, and IL-6 reduced in a concentration-dependent manner by CFEFD treatment (100 ㎍/㎖ - 400 ㎍/㎖) than that by lipopolysaccharide treatment. iNOS and COX-2 protein expressions were inhibited at a concentration of 100 ㎍/㎖ - 400 ㎍/㎖ and 100 ㎍/㎖ - 200 ㎍/㎖, respectively, by the CFEFD treatment. JNK1/2, ERK1/2, p38 and phosphorylated IκBα protein expressions were inhibited in a concentration-dependent manner by the CFEFD treatment. The expression of p65 protein increased in the cytoplasm and was inhibited in the cell nucleus in a concentration-dependent manner.
Conclusions: Water extract of CF exhibited high anti-inflammatory activity, thus having high value as an anti-inflammatory material.
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ABSTRACT
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