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논문 기본 정보

자료유형
학술저널
저자정보
Jonghwan Jegal (Pusan National University) No-June Park (Korea Institute of Science and Technology) Beom-Geun Jo (Pusan National University) Su-Nam Kim (Korea Institute of Science and Technology) Min Hye Yang (Pusan National University)
저널정보
한국생약학회 Natural Product Sciences Natural Product Sciences Vol.25 No.3
발행연도
2019.9
수록면
261 - 267 (7page)

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The rhizomes of Dioscorea japonica Thunb. are widely consumed as food and also used to treat diabetes and polyuria in Korea. This study was undertaken to study the anti-atopic dermatitis effects of a 95% ethanolic extract (DJE) of D. japonica in an oxazolone-stimulated murine model of atopic dermatitis (AD). The therapeutic effects of DJE on AD-like skin lesions were assessed on both ears. DJE (1%) or dexamethasone (0.5%; the positive control) were applied to skin lesions for three weeks. Serum levels of IgE and IL-4 were assessed by ELISA (enzyme-linked immunosorbent assay). Histopathological examinations were performed by hematoxylin and eosin (H&E) and toluidine blue staining and revealed DJE significantly reduced dermal thickness and inflammatory cell infiltration when applied to oxazolone-treated ear skin. DJE-treated AD mice also showed lower serum levels of IgE and IL-4 than oxazolone-stimulated controls. Our findings demonstrate DJE might be a useful safe, topical agent for the treatment of atopic diseases.

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Abstract
Introduction
Experimental
Results and Discussion
References

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