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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 93 - 98 (6page)
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초록· 키워드
오류제보하기
Medicinal plants are potential sources of anticancer agents screening. A large number of phytochemicals, including triterpenoids, have been reported to have significant cytotoxic effects on cancer cells. From the fruits of Ligustrum japonicum Thunb., thirteen triterpenoids (1 - 13) were isolated and evaluated for their cytotoxic activity against Hela and HL-60 cells. As results, 8 (oleanolic acid) showed significant effects on Hela with IC<sub>50</sub> values of 5.5 μM, and moderate effects on HL-60 cells with IC<sub>50</sub> values of 55.9 μM. Meanwhile, 10 (oleanderic acid) and 11 (3β-acetoxy-urs-12-en-28-oic acid) exhibited moderate inhibitory effects on Hela with IC<sub>50</sub> value of 55.0 and 68.8 μM, respectively. Moreover, 10 showed cytotoxic effect on HL-60 cell line with IC<sub>50</sub> value of 63.9 μM. To our knowledge, this is the first report that oleanderic acid was isolated from L. japonicum and investigated in cytotoxic effects on Hela and HL-60 cells.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Jensen, S. R. / 2002 / Phytochemistry 60:213~231
Ngo, Q. -M.T. / 2017 / Phytochemistry 141:147~155
Chudzik, M. / 2015 / Molecules 20:1610~1625
Muhammad Taher / 2016 / Cytotoxic, Anti-Inflammatory and Adipogenic Effects of Inophyllum D, Calanone, Isocordato-oblongic acid, and Morelloflavone on Cell Lines / Natural Product Sciences 22(2):122~128
Tanaka, R. / 1987 / Phytochemistry 26:3365~3366
Ngo, Q. -M.T. / 2017 / Phytochemistry 141:147~155
Chudzik, M. / 2015 / Molecules 20:1610~1625
Muhammad Taher / 2016 / Cytotoxic, Anti-Inflammatory and Adipogenic Effects of Inophyllum D, Calanone, Isocordato-oblongic acid, and Morelloflavone on Cell Lines / Natural Product Sciences 22(2):122~128
Tanaka, R. / 1987 / Phytochemistry 26:3365~3366
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