지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 293 - 298 (6page)
이용수
초록· 키워드
오류제보하기
Plant-derived triterpenoids commonly possesses biological properties such as anti-inflammatory, antimicrobial, anti-viral and anti-cancer. Luvunga scandens is one of the plant that produced triterpenoids. The aims of the study was to analyze cell cycle profile and to determine the expression of p53 unregulated modulator of apoptosis (PUMA), caspase-8 and caspase-9 genes at mRNA level in MCF-7 cell line treated with two triterpenoids, flindissol (1) and 3-oxotirucalla-7,24-dien-21-oic-acid (2) isolated from L. scandens. The compounds were tested for cell cycle analysis using flow cytometer and mRNA expression level using quantitative RT-PCR. The number of MCF-7 cells population which distributed in Sub G1 phase after treated with compound 1 and 2 were 7.7 and 9.3% respectively. The evaluation of the expression of genes showed that both compounds exhibited high level of expression of PUMA, caspase-8 and caspase-9 as normalized to β-actin via activation of those genes. In summary, the isolated compounds of L. scandens plant showed promising anticancer properties in MCF- 7 cell lines.
목차
등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Apoptotic Effects of 6-Gingerol in Human Breast Cancer Cells
International Journal of Oral Biology
2015 .01
-
Comparative Evaluation of Silibinin Effects on Cell Cycling and Apoptosis in Human Breast Cancer MCF-7 and T47D Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients
Clinical Psychopharmacology and Neuroscience
2023 .02
-
Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells
Journal of Breast Cancer
2015 .01
-
Momordica cochinchinensis Aril Extract Induced Apoptosis in Human MCF-7 Breast Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Cytotoxic Effect of Triglycerides via Apoptotic Caspase Pathway in Immune and Non-immune Cell Lines
대한의생명과학회지
2019 .03
-
참옻 추출물의 MCF-7 인체 유방암 세포에서 증식 억제효과
대한한의학방제학회지
2016 .01
-
Phytochemicals from Goniothalamus griffithii Induce Human Cancer Cell Apoptosis
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Glehnia littoralis Root Extract Induces G0/G1 Phase Cell Cycle Arrest in the MCF-7 Human Breast Cancer Cell Line
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Comparison of in Vitro Cytotoxicity and Apoptogenic Activity of Magnesium Chloride and Cisplatin as Conventional Chemotherapeutic Agents in the MCF-7 Cell Line
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Effects of Metformin on Cell Kinetic Parameters of MCF-7 Breast Cancer Cells in Vitro
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
SP1-induced lncRNA MCF2L-AS1 promotes cisplatin resistance in ovarian cancer by regulating IGF2BP1/IGF2/MEK/ERK axis
Journal of Gynecologic Oncology
2022 .11
-
Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms
Journal of Pharmacopuncture
2019 .01
-
Inhibition of Nicotinamide Phosphoribosyltransferase Induces Apoptosis in Estrogen Receptor-Positive MCF-7 Breast Cancer Cells
Journal of Breast Cancer
2017 .01
-
Synergistic Effect of Flavonoids from Artocarpus heterophyllus Heartwoods on Anticancer Activity of Cisplatin Against H460 and MCF-7 Cell Lines
Natural Product Sciences
2019 .12
-
Induction of Apoptosis and Cell Cycle Arrest by Dorema Glabrum Root Extracts in a Gastric Adenocarcinoma (AGS) Cell Line
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Tamoxifen affects heme oxygenase-1 (HO-1) expression in MCF-7 human breast cancer cell line
대한외과학회 학술대회 초록집
2019 .10
-
Use of a Combined Gene Expression Profile in Implementing a Drug Sensitivity Predictive Model for Breast Cancer
Cancer Research and Treatment
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-518-000061520