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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 124 - 131 (8page)
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초록· 키워드
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Phytolaccae Radix has long been used as a traditional indigenous medicine to cure edema and rheumatism. However, there is insufficient background information on toxicological evaluation of Phytolaccae Radix extract to support the safe use. Therefore, we conducted a series of standardized, OECD and KFDA guidelines compliant in vivo study, to find a dose levels for the 13 weeks toxicity study. The extract of Phytolaccae Radix was administered orally to F344 rats at dose levels of 0, 500, 1000 and 2000 mg/kg/day for 2 weeks. Each group was composed to five male and five female rats. In the result, there were no test article-related adverse changes in clinical signs, body weight, food consumption, ophthalmology, hematology, clinical chemistry, gross finding at necropsy and organ weight examination. Therefore, we recommend that 2000 mg/kg/day is a highest treatment group in 13-week exposure study.
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참고문헌 (12)
참고문헌 신청
Jiang, W. Y. / 2005 / Therapeutic wisdom in traditional Chinese medicine: a perspective from modern science / Trends Pharmacol. Sci. 26:558~563
Liu, S. / 2008 / Chinese medicine and separation science / J. Sep. Sci. 31:2113~2137
Zhang, J. / 2012 / Quality of herbal medicines: Challenges and solutions / Complementary Therapies in Medicine 20:100~106
김승현 / 2008 / 승마, 우슬, 인진호, 목단피 및 빈랑자의 독성연구를 위한 안정성 시험 / 생약학회지 39(3):241~245
Won, K. H. / 1998 / A case of aute renal failure and other symptoms associated with Phytolacca Radix poisoning / The Korean J. Nephrology 17:644~648
Liu, S. / 2008 / Chinese medicine and separation science / J. Sep. Sci. 31:2113~2137
Zhang, J. / 2012 / Quality of herbal medicines: Challenges and solutions / Complementary Therapies in Medicine 20:100~106
김승현 / 2008 / 승마, 우슬, 인진호, 목단피 및 빈랑자의 독성연구를 위한 안정성 시험 / 생약학회지 39(3):241~245
Won, K. H. / 1998 / A case of aute renal failure and other symptoms associated with Phytolacca Radix poisoning / The Korean J. Nephrology 17:644~648
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