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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 264 - 272 (9page)
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This study was carried out to evaluate the preventive effect of the Corni Fructus (SSU) 50 % EtOH extract (SSUE50) against bisphenol A (BPA) toxicity in Leydig cells and improving testosterone deficiency syndrome in orchidectomized Sprague-Dawly (SD) rats. Antioxidant properties were measured by radical scavenging activity of SSU-E50 in ABTS assay and DPPH assay. Also, real-time polymerase chain reaction(real-time PCR) was performed to quantify the mRNA expression levels of antioxidant enzyme. SD rats were divided into eight group: normal, sham operation (Sham), orchidectomized (ORX), ORX treated with testosterone 1 mg/kg (Tes. 1), ORX treated with SSU water extract 100 mg/kg (SSU-A 100) and 300 mg/ kg (SSU-A 300), ORX treated with SSU 50 % EtOH extract 100 mg/kg (SSU-E 100) and 300 mg/kg (SSU-E 300). On a comparative basis, the SSU showed better activity quenching ABTS with an IC50 value of 0.29 mg/ml and DPPH with an IC50 value of 0.33 mg/ml. Cell viability was evaluated by MTS assay as described not cytotoxic at the highest concentration of 500 μg/ml. Cytotoxicity of BPA showed in 200 μM, but definitely survived by treatment with SSU in Leydig cells. In addition, SSU increased the mRNA expression levels of antioxidant enzyme in BPA induced Leydig cells. Superoxide dismutase (SOD) level was slightly increased and malondialdehyde (MDA) level was decreased with SSU-A 100 in in-vivo. These results suggest that Corni Fructus extracts have the greatest property as a natural anti-oxidative and improves testosterone deficiency syndrome source.
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참고문헌 (18)
참고문헌 신청
Degen, G. H. / 2000 / Endocrine disruptors:Update on xenoestrogens / Int. Arch. Occup. Environ. Health 73:433~441
고민정 / 2010 / 홍삼섭취가 뇨 중 Bisphenol A 및 MDA 농도에 미치는 영향 / 대한암예방학회지 15(3):231~235
Zirkin, B. R. / 2000 / Regulation of Leydig cell steroidogenic fuction during aging / Biol. Reprod 63:977~981
Heather Patisaul / 2009 / Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior / Frontiers in Behavioral Neuroscience 3
이창복 / 2003 / 원색 대한식물도감 / 향문사
고민정 / 2010 / 홍삼섭취가 뇨 중 Bisphenol A 및 MDA 농도에 미치는 영향 / 대한암예방학회지 15(3):231~235
Zirkin, B. R. / 2000 / Regulation of Leydig cell steroidogenic fuction during aging / Biol. Reprod 63:977~981
Heather Patisaul / 2009 / Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior / Frontiers in Behavioral Neuroscience 3
이창복 / 2003 / 원색 대한식물도감 / 향문사
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