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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 211 - 216 (6page)
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초록· 키워드
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In the course of our continuing search for biologically active components from Korean medicinal plants, we isolated the main compound, luteolin 5-glucoside from aqueous fraction of Ajuga spectabilis. The structure was elucidated by the basis of <SUP>1</SUP>H and <SUP>13</SUP>C NMR and TOF ESI-MS data. Quantitative analysis of luteolin 5-glucoside was carried out on a XBridge C18 column (S-5 μm, 4.6×250 mm) with gradient elution composed of acetonitrile:water. The results exhibit that the average content of main compound in A. spectabilis were 0.048%. Oxidative stress plays a major role Alzheimer’s disease (AD) and other neurodogenerative disease. AD is major health problem and there is currently no clinically accepted treatment to cure or stop its progression. Pretreatment with luteolin 5-glucoside markedly attenuated H₂O₂-induced cell viability loss in a dose-dependent manner. Luteolin 5-glucoside also inhibited the formation of intracellular reactive oxygen species in SH-SY5Y. The results suggest that luteolin 5-glucoside from A. spectabilis has protective effects against oxidative stress induced cytotoxicity, which might be a potential therapeutic compound for treating and/or preventing neurodegenerative disease implicated with oxidative stress.
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참고문헌 (12)
참고문헌 신청
Collins, J. A. / 2016 / Oxidative stress promotes peroxiredoxin hyperoxidation and attenuates pro-survival signaling in aging chondrocytes / J. Biol. Chem. 291:6641~6654
이승욱 / 2005 / 울릉도산 산채류 추출물의 총 폴리페놀 함량 및 항산화 활성 / 한국식품과학회지 37(2):233~240
Huang, S. H. / 2008 / Protective effects of Angelica sinensis extract on amyloid beta-peptideinduced neurotoxicity / Phytomedicine 15:710~721
Sabogal-Guaqueta, A. M. / 2015 / The flavonoid quercetin ameliorates alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic alzheimer's disease model mice / Neuropharmacology 93:134~145
Zhang, Y. C. / 2013 / Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury / Food Chem. Toxicol. 59:272~280
이승욱 / 2005 / 울릉도산 산채류 추출물의 총 폴리페놀 함량 및 항산화 활성 / 한국식품과학회지 37(2):233~240
Huang, S. H. / 2008 / Protective effects of Angelica sinensis extract on amyloid beta-peptideinduced neurotoxicity / Phytomedicine 15:710~721
Sabogal-Guaqueta, A. M. / 2015 / The flavonoid quercetin ameliorates alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic alzheimer's disease model mice / Neuropharmacology 93:134~145
Zhang, Y. C. / 2013 / Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury / Food Chem. Toxicol. 59:272~280
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