메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색
질문

논문 기본 정보

자료유형
학술저널
저자정보
Woo-Sang Jung (Kyung Hee University) Seungwon Kwon (Kyung Hee University) Jung Yun Yang (Kyung Hee University) Chul Jin (Kyung Hee University) Seung-Yeon Cho (Kyung Hee University) Seong-Uk Park (Kyung Hee University) Sang-Kwan Moon (Kyung Hee University) Jung-Mi Park (Kyung Hee University) Chang-Nam Ko (Kyung Hee University) Hyunsu Bae (Kyung Hee University) Ki-Ho Cho (Kyung Hee University)
저널정보
대한한의학회 대한한의학회지 대한한의학회지 제43권 제2호
발행연도
2022.6
수록면
1 - 9 (9page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색
질문

초록· 키워드

오류제보하기
Objectives: Bee venom (BV) is a widely used therapy in Traditional East Asian Medicine (TEAM). We previously reported that BV was clinically effective for treating Parkinson’s disease, that phospholipase A₂ (PLA₂) was the main component of BV, and that it induced regulatory T cells (Tregs) by binding CD206 on dendritic cells (DCs). Therefore, we aimed to reconfirm our findings in human blood samples and investigate the relationship between CD206<SUP>+</SUP> DCs and clinical syndrome differentiation in TEAM.
Methods: We surveyed 100 subjects with questionnaires on cold-heat patternization and obtained their blood samples. The obtained human peripheral blood monocytes (hPBMCs) were washed with phosphate-buffered saline (PBS). After resuspension with ex vivo media, numbers of cells were counted. Tregs were counted after culturing the samples in a 37℃ CO₂ incubator for 72 h.
Results: We divided the subjects into a relatively high CD206<SUP>+</SUP> group or a relatively low CD206<SUP>+</SUP> group. The heat factor scores of high CD206<SUP>+</SUP> group were significantly higher than that of low CD206<SUP>+</SUP> group (high vs low: 239.2 ± 54.1 vs 208.4 ± 55.1, p=0.023). After culturing with PLA₂, Tregs increased in the high CD206<SUP>+</SUP> group but decreased in the low CD206+ group.
Conclusion: In this study, we reconfirm that CD206<SUP>+</SUP> DCs induced Treg differentiation by incubating human blood samples with PLA₂ and that they showed an association with syndrome differentiation, especially with heat patterns, in TEAM. A heat pattern in TEAM might be one indication for PLA₂ therapy because its score was elevated in the high CD206<SUP>+</SUP> group.

목차

Introduction
Methods
Results
Discussion
References

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0