지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.2
- 수록면
- 363 - 373 (11page)
이용수
초록· 키워드
오류제보하기
Multi-omics data is difficult to interpret due to the heterogeneity of information by the volume of data, the complexity of characteristics of each data, and the diversity of omics platforms. There is not yet a system for interpreting to visualize research data on environmental diseases concerning environmental harmful substances. We provide MEE, a web-based visualization tool, to comprehensively explore the complexity of data due to the interconnected characteristics of high-dimensional data sets according to exposure to various environmental harmful substances. MEE visualizes omics data of correlation between omics data, subjects and samples by keyword searches of meta data, multi-omics data, and harmful substances. MEE has been demonstrated the versatility by two examples. We confirmed the correlation between smoking and asthma with RNA-seq and Methylation-Chip data, it was visualized that genes (PHACTR3, PXDN, QZMB, SOCS3 etc.) significantly related to autoimmune or inflammatory diseases. To visualize the correlation between atopic dermatitis and heavy metals, we selected 32 genes related immune response by integrated analysis of multi-omics data. However, it did not show a significant correlation between mercury in blood and atopic dermatitis. In the future, should continuously collect an appropriate level of multi-omics data in MEE system, will obtain data to analyze environmental substances and diseases.
목차
ABSTRACT
1. 서론
2. 재료 및 방법
3. 결과 및 고찰
4. 결론
REFERENCE
참고문헌 (17)
참고문헌 신청
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S.B. Koh, “Environmental Diseases,” Journal of the Korean Medical Association, Vol. 55, No. 3, pp. 212-213, 2012
O. Robinson and M. Vrijheid, “The Pregnancy Exposome,” Current Environmental Health Report, Vol. 2, pp. 204-213, 2015.
F. Grun and B. Blumberg, “Environmental Obesogens: Organotinsand Endocrine Disruption via Nuclear Receptor Signaling,” Endocrinology, Vol. 147, pp. S50-S55, 2006.
R. Vermeulen, E.L. Schymanski, A.L. Barabási, and G.W. Miller, “The Exposome and Health: Where Chemistry Meets Biology,” Science. Vol. 367, No. 6476, pp. 392-396, 2020.
S.B. Koh, “Environmental Diseases,” Journal of the Korean Medical Association, Vol. 55, No. 3, pp. 212-213, 2012
O. Robinson and M. Vrijheid, “The Pregnancy Exposome,” Current Environmental Health Report, Vol. 2, pp. 204-213, 2015.
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UCI(KEPA) : I410-ECN-0101-2022-004-001088931