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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 196 - 206 (11page)
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Hepatocyte-like cells (HLCs) derived from human pluripotent stem cells are a promising cell source for drug screening and toxicity tests. Thus, various hepatic differentiating protocols have been developed, leading to a hepatic differentiation efficiency of approximately 90%. However, HLC drug metabolizing ability remains very low compared to human primary hepatocytes. In order to overcome this problem, several alternative methods, such as, co-culture, three-dimensional (3D) culture, bioreactor, nanochip-based, etc., have been developed, but optimization to produce fully functional HLCs is ongoing. Recently, our group reported that repeated exposure of HLCs to xenobiotics can improve the expression of hepatic metabolizing enzymes such as cytochrome P450s (CYPs) and glutathione S-transferases (GSTs). These data suggest that we should develop strategies for differentiating cells into mature HLCs by more closely mimicking in vivo fetal and postnatal liver development. Here, we review the current development of alternative methods for enhancing the drug metabolizing functions of HLCs derived from human embryonic stem cells, human-induced pluripotent stem cells, and mesenchymal stem cells as used for drug screening and toxicity tests.
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참고문헌 (54)
참고문헌 신청
Kia R / 2013 / Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet? / Br J Clin Pharmacol 75:885~896
Kim JH / 2015 / Enhanced metabolizing activity of human ES cell-derived hepatocytes using a 3D culture system with repeated exposures to xenobiotics / Toxicol Sci 147:190~206
Subramanian K / 2014 / Spheroid culture for enhanced differentiation of human embryonic stem cells to hepatocyte-like cells / Stem Cells and Dev 23:124~131
The world’s first commercial human iPSC-derived hepatocytes
Schwartz RE / 2014 / Pluripotent stem cell-derived hepatocyte-like cells / Biotechnology Adv 32:504~513
Kim JH / 2015 / Enhanced metabolizing activity of human ES cell-derived hepatocytes using a 3D culture system with repeated exposures to xenobiotics / Toxicol Sci 147:190~206
Subramanian K / 2014 / Spheroid culture for enhanced differentiation of human embryonic stem cells to hepatocyte-like cells / Stem Cells and Dev 23:124~131
The world’s first commercial human iPSC-derived hepatocytes
Schwartz RE / 2014 / Pluripotent stem cell-derived hepatocyte-like cells / Biotechnology Adv 32:504~513
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