지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 449 - 456 (8page)
이용수
초록· 키워드
오류제보하기
Adiponectin (APN; ACRP30, AdipoQ), one of the best characterized adipokine, is a multifaceted, pleiotrophic cytokine that plays important roles in the regulation of lipid metabolism/obesity, inflammation/autoimmunity, and vascular function. APN expression is closely associated with pathology of chronic inflammatory and autoimmune diseases including rheumatoid arthritis. It exists as multiple forms including monomer, dimer, trimer, and high molecular weight oligomers. In addition, enzymatic digestion leads to the formation of smaller globular domain. While full length APN in a number of biological events has been investigated, the role of globular domain is elusive. Here, we showed that globular fragment of APN (gAPN) plays a role in murine hematopoiesis. Upon single systemic injection of 5 μg of gAPN to C57BL/6 mice, there was a marked increase in the blood leukocyte counts, mostly myeloid cells, after 3 days of gAPN treatment. While intraperitoneal injection did not affect the peripheral blood cellularity, subcutaneous gAPN injection significantly reduce the number of leukocytes in the peripheral blood. Lin-c-kit+ primitive hematopoietic progenitor cells were also mobilized into the peripheral blood of gAPN-treated mice with similar kinetics and magnitude to that of granulocytes and lymphocytes. Kinetics of plasma granulocyte colony stimulating factor (G-CSF) release by gAPN administration revealed that G-CSF is the key mediator for gAPN-induced leukocytosis and hematopoietic stem/progenitor cells mobilization. These observations suggest that leukocyte elastase or other extracellular proteases released from activated monocytes/neutrophils during immune responses generates globular APN and this cytokine serves as a potent mobilizer of hematopoietic progenitors and leukocytes into the peripheral blood.
목차
등록된 정보가 없습니다.
참고문헌 (45)
참고문헌 신청
Scherer PE / 1995 / A novel serum protein similar to C1q, produced exclusively in adipocytes / J Biol Chem 270:26746~26749
Maeda K / 1996 / cDNA cloning and expression of a novel adipose specific collagenlike factor, apM1 (AdiPose Most abundant Gene transcript 1) / Biochem Biophys Res Commun 221:286~289
Hotta K / 2000 / Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients / Arterioscler Thromb Vasc Biol 20:1595~1599
Bobbert T / 2005 / Changes of adiponectin oligomer composition by moderate weight reduction / Diabetes 54:2712~2719
Ouchi N / 2003 / Obesity, adiponectin and vascular inflammatory disease / Curr Opin Lipidol 14:561~566
Maeda K / 1996 / cDNA cloning and expression of a novel adipose specific collagenlike factor, apM1 (AdiPose Most abundant Gene transcript 1) / Biochem Biophys Res Commun 221:286~289
Hotta K / 2000 / Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients / Arterioscler Thromb Vasc Biol 20:1595~1599
Bobbert T / 2005 / Changes of adiponectin oligomer composition by moderate weight reduction / Diabetes 54:2712~2719
Ouchi N / 2003 / Obesity, adiponectin and vascular inflammatory disease / Curr Opin Lipidol 14:561~566
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
실리콘 기판 위의 광전소자 집적화를 위한 InGaPN/GaPN 양자우물 레이저의 광학적 특성 연구
대한전자공학회 학술대회
2019 .06
-
Drosophila blood as a model system for stress sensing mechanisms
BMB Reports
2015 .01
-
BMP4 and perivascular cells promote hematopoietic differentiation of human pluripotent stem cells in a differentiation stage-specific manner
Experimental and Molecular Medicine
2020 .01
-
Effect of Low Magnitude High Frequency Vibration on Osteogenic Differentiation of Periosteum Derived Progenitor Cells
한국생물공학회 학술대회
2018 .10
-
수혈 부작용 예방을 위한 백혈구 제거 혈액 필터의 제조와 성능평가
한국섬유공학회지
2019 .01
-
Role of Stromal Cell-Derived Factor-1 in Endothelial Progenitor Cell-Mediated Vascular Repair and Regeneration
조직공학과 재생의학
2021 .10
-
The M-CSF receptor in osteoclasts and beyond
Experimental and Molecular Medicine
2020 .08
-
Local Injection of Granulocyte-Colony Stimulating Factor Accelerates Wound Healing in a Rat Excisional Wound Model
조직공학과 재생의학
2016 .01
-
The QbD Approach for Manufacturing Stem Cell-derived Artificial Red Blood Cells
한국생물공학회 학술대회
2023 .04
-
The anti-microbial peptide SR-0379 stimulates human endothelial progenitor cell-mediated repair of peripheral artery diseases
BMB Reports
2017 .01
-
Adiponectin Inhibits Mouse Mammary Tumor Growth and Reduced Tumor-Induced Hematopoiesis
조직공학과 재생의학
2015 .01
-
Neuropeptide Y-based recombinant peptides ameliorate bone loss in mice by regulating hematopoietic stem/progenitor cell mobilization
BMB Reports
2017 .01
-
심근유래의 줄기세포 프라이밍 및 조직공학 기술에 의한 심혈관 재생 전략
KSBB Journal
2018 .09
-
GM-CSF Enhances Mobilization of Bone Marrow Mesenchymal Stem Cells via a CXCR4-Medicated Mechanism
조직공학과 재생의학
2019 .01
-
Efficient Generation of Spatiotemporal Images for Leukocyte Motion Detection in Microvessels
IEIE Transactions on Smart Processing & Computing
2017 .04
-
Globular Proteinosome: Next-Generation Synthetic Vesicle Self-Assembled from Recombinant Fusion Proteins
한국고분자학회 학술대회 연구논문 초록집
2019 .04
-
Lineage tracking to reveal the fate of hematopoietic stem cells influenced by Flk2− multipotent progenitors after transplantation
Experimental and Molecular Medicine
2023 .01
-
Generating Natural Killer Cells from Hematopoietic Stem Cells for Cancer Immunotherapy
한국생물공학회 학술대회
2017 .04
-
Corpuscular volume estimation using a small amount of blood via microscope images
제어로봇시스템학회 국제학술대회 논문집
2023 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0