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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 427 - 434 (8page)
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Recently, studies have focused more towards using biocompatible scaffolds and stem cells to augment or replace the abnormal bladder. But, due to the lack of biomaterials with appropriate thickness as a suitable scaffold for smooth muscle regeneration, several structural, mechanical, and biocompatibility problems are encountered. Therefore, we aimed to demonstrate whether human muscle-derived stem cells (h-MDSCs) seeded on multilayered polycaprolactone (PCL) nanofiber is an appropriate scaffold for bladder smooth muscle regeneration. h-MDSCs were seeded on a multilayered PCL/collagen nanofiber sheet and implanted in the bladder of a mucosa preserving partial cystectomy rat. From our findings, h-MDSCs seeded on multilayered PCL showed efficient cell seeding and proliferation. In addition, the histological and immunohistochemical analysis showed cell survival in between the multilayered nanofiber sheet, which led to smooth muscle cell regeneration with improved pro-angiogenesis in the regenerated region of the bladder. Therefore, h-MDSCs seeded nanofibers could be a promising tool in treating neurogenic bladder and related diseases.
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참고문헌 (35)
참고문헌 신청
Engelhardt EM / 2011 / A collagen-poly(lactic acid-co-ε-caprolactone)hybrid scaffold for bladder tissue regeneration / Biomaterials 32:3969~3976
Atala A / 2001 / Bladder regeneration by tissue engineering / BJU Int 88:765~770
Atala A / 2006 / Tissue-engineered autologous bladders for patients needing cystoplasty / Lancet 367:1241~1246
Jack GS / 2009 / Urinary bladder smooth muscle engineered from adipose stem cells and a three dimensional synthetic composite / Biomaterials 30:3259~3270
박준범 / 2013 / Establishment of the Chronic Bone Defect Model in Experimental Model Mandible and Evaluation of the Efficacy of the Mesenchymal Stem Cells in Enhancing Bone Regeneration / 조직공학과 재생의학 10(1):18~24
Atala A / 2001 / Bladder regeneration by tissue engineering / BJU Int 88:765~770
Atala A / 2006 / Tissue-engineered autologous bladders for patients needing cystoplasty / Lancet 367:1241~1246
Jack GS / 2009 / Urinary bladder smooth muscle engineered from adipose stem cells and a three dimensional synthetic composite / Biomaterials 30:3259~3270
박준범 / 2013 / Establishment of the Chronic Bone Defect Model in Experimental Model Mandible and Evaluation of the Efficacy of the Mesenchymal Stem Cells in Enhancing Bone Regeneration / 조직공학과 재생의학 10(1):18~24
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