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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective：Memory Impairment has been proposed as the first sign in preclinical and early Alzheimer’s disease (AD). This study aims to assess the utility of a new memory test based on Free and Cued Selective Reminding Test using pattern cue that seems useful for detecting memory impairments associated with AD.
Methods：Twenty-six patients with mild cognitive impairment, 24 AD patients at a mild stage, 35 normal controls and 8 Lewybody dementia (LBD) patients at a mild stage took part in the study. A newly devised Pattern Cued Recall Test (PCRT) was compared with established memory test, the word list recall from the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K). To assess the ability of the PCRT subtests and CERAD-K to screen dementia, receiver operating characteristic curves were plotted.
Results：The distinctive feature of the PCRT was that encoding specificity was increased by adding an immediate cued recall stage at the encoding phase. PCRT was confirmed as having sufficient validity to diagnose dementias. Compared to CERAD-K, the PCRT had similar accuracy of discriminating AD. But the analysis showed better diagnostic validity of PCRT than CERAD-K in LBD. Therefore, this test appears to be, especially, well suited for the diagnosis of mild LBD.
Conclusion：This study showed that a memory test based on controlled encoding and retrieval condition and especially using pattern cue could be effective methodology for mild AD and LBD from normal control. PCRT could be an alternative to diagnose LBD by testing visual impairments, which is a hallmark symptom of LBD. Therefore, a further clinical study should be promising.
목차
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참고문헌 (30)
참고문헌 신청
Jacobs DM / 1995 / Neuropsychological detection and characterization of preclinical Alzheimer’s disease / Neurology 45:957~962
Petersen RC / 1994 / Memory function in very early Alzheimer’s disease / Neurology 44:867~872
Tuokko H / 1991 / Cued recall and early identification of dementia / J Clin Exp Neuropsychol 13:871~879
Ivanoiu A / 2005 / Memory evaluation with a new cued recall test in patients with mild cognitive impairment and Alzheimer’s disease / J Neurol 252:47~55
Buschke H / 1997 / Diagnosis of early dementia by the Double Memory Test : encoding specificity improves diagnostic sensitivity and specificity / Neurology 48:989~997
Petersen RC / 1994 / Memory function in very early Alzheimer’s disease / Neurology 44:867~872
Tuokko H / 1991 / Cued recall and early identification of dementia / J Clin Exp Neuropsychol 13:871~879
Ivanoiu A / 2005 / Memory evaluation with a new cued recall test in patients with mild cognitive impairment and Alzheimer’s disease / J Neurol 252:47~55
Buschke H / 1997 / Diagnosis of early dementia by the Double Memory Test : encoding specificity improves diagnostic sensitivity and specificity / Neurology 48:989~997
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