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학술저널
저자정보
이천우 (울산대학교) 유달산 (서울아산병원) 정인갑 (울산대학교) 홍준혁 (울산대학교) 주명수 (울산대학교) 안한종 (울산대학교) 안태영 (울산대학교) 김청수 (울산대학교)
저널정보
대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.56 No.6
발행연도
2015.1
수록면
466 - 472 (7page)

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Purpose: To assess the rates of infectious complications before and after the change of prophylactic antibiotic regimens in prostateneedle biopsy. Materials and Methods: The records of 5,577 patients who underwent prostate needle biopsy at Asan Medical Center betweenAugust 2005 and July 2012 were retrospectively reviewed. Group 1 (n=1,743) included patients treated between 2005 and 2009with fluoroquinolone for 3 days, group 2 (n=2,723) included those treated between 2009 and 2012 with ceftriaxone once beforethe biopsy and fluoroquinolone before biopsy and continue therapy for 3 days, and group 3 (n=1,111) received the same treatmentfor more than 7 days after the biopsy. Univariable and multivariable logistic regression models addressed risk factors associatedwith infectious complication after prostate needle biopsy. Results: Infectious complication after prostate needle biopsy developed in 18 (group 1), seven (group 2), and two patients (group3) (p=0.001). In group 1, seven patients with infectious complication had positive blood cultures and harbored fluoroquinolone-resistantEscherichia coli , four had ceftriaxone susceptible isolates, and three had extended spectrum beta-lactamase-positive E. coli . Two patients in group 1 required intensive care because of septic shock. In multivariable analysis, the patients with combination offluoroquinolone and ceftriaxone had significantly lower infectious complication rate than the fluoroquinolon alone (p=0.003). Conclusions: Antibiotic prophylaxis with ceftriaxone and fluoroquinolone before prostate needle biopsy decreased the risk of potentiallyserious infectious complications.

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