지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 12 - 18 (7page)
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The therapeutic effects and side effects of androgen deprivation therapy (ADT), which is a main treatment method for metastaticprostate cancer, are well known, but the metabolic effects have only recently been studied. This review describes the effects of ADTon body habitus, insulin resistance, lipid profiles, diabetes, metabolic syndrome, and cardiovascular morbidity and mortality. Thereview was done by using KoreaMed and PubMed to search the medical literature related to prostate cancer, ADT, body habitus,lipid profile, diabetes, insulin resistance, metabolic syndrome, and cardiovascular disease. ADT increases fat mass and decreaseslean body mass. Fat mostly accumulates in the subcutaneous area. ADT increases total cholesterol, triglycerides, and high-densitylipoprotein, as well as the risk for insulin resistance and diabetes. ADT also increases the risk for cardiovascular events, but insufficientevidence is available for a correlation with mortality. ADT changes body habitus and lipid profiles and has different characteristicsthan those of classic metabolic syndrome, but it is related to insulin resistance and diabetes. ADT increases the risk forcardiovascular events. No consistent guidelines have been proposed for treating the metabolic effects of ADT, but the generallyrecommended treatment methods for lowering the risk of diabetes and cardiovascular disease should be fully understood. Additionalstudies are necessary.
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참고문헌 (46)
참고문헌 신청
Siegel R / 2011 / Cancer statistics, 2011:the impact of eliminating socioeconomic and racial disparities on premature cancer deaths / CA Cancer J Clin 61:212~236
Ferlay J / 2010 / Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 / Int J Cancer 127:2893~2917
Baade PD / 2009 / International epidemiology of prostate cancer: geographical distribution and secular trends / Mol Nutr Food Res 53:171~184
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Mottet N / 2011 / EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer / Eur Urol 59:572~583
Ferlay J / 2010 / Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 / Int J Cancer 127:2893~2917
Baade PD / 2009 / International epidemiology of prostate cancer: geographical distribution and secular trends / Mol Nutr Food Res 53:171~184
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Mottet N / 2011 / EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer / Eur Urol 59:572~583
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