지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 593 - 602 (10page)
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초록· 키워드
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Purpose The purpose of this study was to evaluate the association of androgen deprivation therapy (ADT) with cognitive dysfunction. Materials and Methods Using the National Health Insurance Service database of the entire Korean adult prostate cancer population (n=236,391), data on ADT and cognitive dysfunction between 2008 and 2015 were analyzed. We excluded patients previously diagnosed with cognitive dysfunction, dementia, or a cerebral event history. We tested the effect of ADT on the risk of cognitive dysfunction using propensity score–matched Cox proportional hazards regression models and Kaplan-Meier survival analysis. Our final cohort comprised of 35,401 individuals with prostate cancer, including 24,567 men (70.6%) who underwent ADT. Results During a mean follow-up period of 4.1 years, 4,741 patients were newly diagnosed with cognitive dysfunction. A statistically significant association was found between ADT and the risk of cognitive dysfunction (hazard ratio, 1.169; p=0.002). Meanwhile, age ( 70 years), diabetes, hypertension, cardiovascular history, and peripheral vascular disease were identified as factors that contribute to the increased risk of cognitive dysfunction. In contrast, the use of statins and aspirin was associated with a lower risk of cognitive dysfunction. Kaplan-Meier analysis demonstrated that patients aged 70 years or older who underwent ADT had the lowest cumulative probability of remaining cognitive dysfunction-free (log-rank p < 0.001). Conclusion Our results revealed an association between the use of ADT for the treatment of prostate cancer and an increased risk of cognitive dysfunction in a nationwide population-based study. This finding should be further evaluated in prospective studies.
목차
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참고문헌 (34)
참고문헌 신청
Bolla M / 2002 / Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer(an EORTC study) : a phase III randomised trial / Lancet 360:103~106
Shahinian VB / 2005 / Increasing use of gonadotropin-releasing hormone agonists for the treatment of localized prostate carcinoma / Cancer 103:1615~1624
Taylor LG / 2009 / Review of major adverse effects of androgen-deprivation therapy in men with prostate cancer / Cancer 115:2388~2399
최세민 / 2015 / Metabolic effects of androgen deprivation therapy / Investigative and Clinical Urology 56(1):12~18
Kintzel PE / 2008 / Increased risk of metabolic syndrome, diabetes mellitus, and cardiovascular disease in men receiving androgen deprivation therapy for prostate cancer / Pharmacotherapy 28:1511~1522
Shahinian VB / 2005 / Increasing use of gonadotropin-releasing hormone agonists for the treatment of localized prostate carcinoma / Cancer 103:1615~1624
Taylor LG / 2009 / Review of major adverse effects of androgen-deprivation therapy in men with prostate cancer / Cancer 115:2388~2399
최세민 / 2015 / Metabolic effects of androgen deprivation therapy / Investigative and Clinical Urology 56(1):12~18
Kintzel PE / 2008 / Increased risk of metabolic syndrome, diabetes mellitus, and cardiovascular disease in men receiving androgen deprivation therapy for prostate cancer / Pharmacotherapy 28:1511~1522
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