지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.68 No.2
- 발행연도
- 2015.1
- 수록면
- 159 - 169 (11page)
이용수
초록· 키워드
오류제보하기
Background: The objective of this study was to investigate the time-course of the expression of TNF-α, IL-6, and IL-1βafter L5 spinal nerve transection (SNT), and to determine the effect of small interfering RNA (siRNA) targeting these cytokineson neuropathic pain.
Methods: Rats received control siRNA (CON group, n = 80) or a cocktail of siRNAs targeting these cytokines (COCK group,n = 70). The siRNAs were given via intrathecal catheter 1 d prior to SNT, on the operation day, and 1, 2 and 3 d postoperatively.
Behavioral tests and levels of the cytokine mRNAs and proteins as well as glial cell activity were following the L5 SNT.
Results: In the CON group, TNF-α and IL-1β mRNA levels increased immediately after SNT and remained high for 6 d,while IL-6 transcripts only began to increase after 12 h. TNF-α and IL-1β mRNA levels in the COCK group were lowerthan in the CON group at all time points (P < 0.05). In the behavioral tests, allodynia and hyperalgesia were significantlylower in the COCK group from 2 d after SNT (P < 0.05).
Conclusions: The time courses of TNF-α, IL-6 and IL-1β mRNA expression after L5 SNT differ. RNA interference maybe a method of reducing the development of mechanical allodynia and hyperalgesia in response to nerve injury.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Jensen TS / 2003 / Translation of symptoms and signs into mechanisms in neuropathic pain / Pain 102:1~8
Mika J / 2013 / Importance of glial activation in neuropathic pain / Eur J Pharmacol 716:106~119
DeLeo JA / 1996 / Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model / J Interferon Cytokine Res 16:695~700
Malcangio M / 1996 / Effect of interleukin-1 beta on the release of substance P from rat isolated spinal cord / Eur J Pharmacol 299:113~118
Schäfers M / 2003 / Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons / J Neurosci 23:2517~2521
Mika J / 2013 / Importance of glial activation in neuropathic pain / Eur J Pharmacol 716:106~119
DeLeo JA / 1996 / Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model / J Interferon Cytokine Res 16:695~700
Malcangio M / 1996 / Effect of interleukin-1 beta on the release of substance P from rat isolated spinal cord / Eur J Pharmacol 299:113~118
Schäfers M / 2003 / Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons / J Neurosci 23:2517~2521
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