지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 985 - 989 (5page)
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The aim of this study was to test the impact of variants rs900400 (located near LEKR1 and CCNL1) and rs9883204 (located in ADCY5) on birth weight in a Chinese population. We conducted a case–control study including 156 low-birth- weight infants as the case group and 100 normal-birth-weight infants as the control group. The rs900400 and rs9883204 variants were analyzed by gene sequencing in all the participants. Our results revealed a significant difference in the genotype distribution (v2 = 10.449, p = 0.005) and allele distribution (v2 = 9.277, p = 0.002) of rs900400 between the case group and the control group. The C allele of rs900400 was associated with lower birth weight (OR 1.771 [95 % CI 1.237–2.535]) in the Chinese population. However, the rs9883204 polymorphism was not informative in the Chinese population. Our study shows that the ‘‘birth weightlowering’’ variant rs900400 located near LEKR1 and CCNL1, which is strongly associated with birth weight in European cohorts, appears to have a similar association in Chinese cohorts. However, the rs9883204 variant located in ADCY5 does not appear to be correlated with low birth weight in the same population. Moreover, we found that the variant rs900400 may also be associated with premature birth, thereby supporting the need for further research in this area.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Acker DB / 1985 / Risk factors for shoulder dystocia / Obstet Gynecol 66:762~768
Babenko AP / 2006 / Activating mutations in the ABCC8 gene in neonatal diabetes mellitus / N Engl J Med 355:456~466
Barker DJ / 1993 / Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth / Diabetologia 36:62~67
Battaglia FC / 1967 / A practical classification of newborn infants by weight and gestational age / J Pediatr 71:159~163
Clausson B / 2000 / Genetic influence on birthweight and gestational length determined by studies in offspring of twins / BJOG 107:375~381
Babenko AP / 2006 / Activating mutations in the ABCC8 gene in neonatal diabetes mellitus / N Engl J Med 355:456~466
Barker DJ / 1993 / Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth / Diabetologia 36:62~67
Battaglia FC / 1967 / A practical classification of newborn infants by weight and gestational age / J Pediatr 71:159~163
Clausson B / 2000 / Genetic influence on birthweight and gestational length determined by studies in offspring of twins / BJOG 107:375~381
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