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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 875 - 882 (8page)
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초록· 키워드
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Apolipoprotein A1 (ApoA1) plays an important role in reverse cholesterol transport. The functional abnormality of ApoA1 is known to be the major risk for lipid disorders or cardiovascular diseases. In this study, we examined the associations of two ApoA1 polymorphisms (XmnI and MspI/rs670) with the Korean patients with metabolic syndrome (MetS). A total of 835 subjects were investigated, which includes 320 patients with MetS and 515 healthy controls. Genotyping of the ApoA1 polymorphisms was analyzed by conventional polymerase chain reaction and digestions with restriction endonucleases. The mutant genotypes of the XmnI and MspI polymorphisms were associated with the decreased risk of MetS. The X1-A and X2-G haplotypes for the XmnI and MspI polymorphisms were also protective to susceptibility for MetS. The XmnI and MspI polymorphisms showed significant associations with DBP (P = 0.047) and body mass index (P = 0.037) among MetS risk factors, respectively. Stratified analysis for MetS risk components was significantly associated between the XmnI polymorphism and blood pressure. Based on these results, the variants and haplotypes of the ApoA1 polymorphisms may be protective against MetS susceptibility in Koreans.
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참고문헌 (26)
참고문헌 신청
Clemente-Postigo M / 2010 / Effect of apolipoprotein C3 and apolipoprotein A1 polymorphisms on postprandial response to a fat overload in metabolic syndrome patients / Clin Biochem 43:1300~1304
Coban N / 2014 / Gender-specific associations of the APOA1 -75G > A polymorphism with several metabolic syndrome components in Turkish adults / Clin Chim Acta 431:244~249
Dallinga-Thie GM / 1996 / Apolipoprotein A-I/C-III/A-IV gene cluster in familial combined hyperlipidemia: effects on LDL-cholesterol and apolipoproteins B and C-III / J Lipid Res 37:136~147
Dodani S / 2011 / Metabolic syndrome in South Asian immigrants: more than low HDL requiring aggressive management / Lipids Health Dis 10:45
Dodani S / 2012 / Apo lipoprotein A1 gene polymorphisms predict cardio-metabolic risk in South Asian immigrants / Dis Markers 32:9~19
Coban N / 2014 / Gender-specific associations of the APOA1 -75G > A polymorphism with several metabolic syndrome components in Turkish adults / Clin Chim Acta 431:244~249
Dallinga-Thie GM / 1996 / Apolipoprotein A-I/C-III/A-IV gene cluster in familial combined hyperlipidemia: effects on LDL-cholesterol and apolipoproteins B and C-III / J Lipid Res 37:136~147
Dodani S / 2011 / Metabolic syndrome in South Asian immigrants: more than low HDL requiring aggressive management / Lipids Health Dis 10:45
Dodani S / 2012 / Apo lipoprotein A1 gene polymorphisms predict cardio-metabolic risk in South Asian immigrants / Dis Markers 32:9~19
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