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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 173 - 181 (9page)
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초록· 키워드
오류제보하기
High triglyceride (TG) levels are known to beassociated with complex diseases such as cardiovasculardisease. Here, we evaluated the effect of interactionsbetween genetic polymorphisms and environmental factorson plasma TG levels in a Korean aging cohort. Thirty-twosingle nucleotide polymorphism (SNP) markers located inseven genes (ADLH2, APOE, GCKR, MC4R, TCF7L2,GATA2, and HNF1A) for TG levels were genotyped in 714older Koreans (mean age, 68 years). We performed multiplelinear regression analyses for these SNP markersunder three genetic models (i.e. additive, dominant, andrecessive) and evaluated their associations with multipleenvironmental factors, including obesity, systolic bloodpressure, and drinking and smoking habits. We foundevidence for four SNP-smoking interactions. The CCgenotype of rs1260326 (GCKR) interacted with currentsmoking for lower TG levels (PG9E = 0.017). TG levelswere higher in smokers with the GG genotype ofrs2713604 (GATA2) than in those with the GA ? AAgenotypes (195.6 and 145.7 mg/dL, respectively,PG9E = 0.029). The GA ? AA genotypes of rs2713603(GATA2) were associated with elevated TG levels insmokers when compared to non-smokers carrying the GGgenotype (180.6 mg/dL vs. 148.3 mg/dL, PG9E = 0.046).
The C allele of rs2464196 (HNF1A) interacted with currentsmoking for elevated TG levels (PG9E = 0.028). The geneand cigarette smoking interactions shown in this study needto be validated in a large-scale study.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Ariza MJ / 2010 / Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study / BMC Med Genet 11:66
Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21:263~265
Cauchi S / 2008 / The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies / BMC Med Genet 9:45
Cho YG / 2009 / The relationship between body fat mass and erectile dysfunction in Korean men: Hallym Aging Study / Int J Impot Res 21:179~186
Connelly JJ / 2006 / GATA2 is associated with familial early-onset coronary artery disease / PLoS Genet 2:e139
Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21:263~265
Cauchi S / 2008 / The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies / BMC Med Genet 9:45
Cho YG / 2009 / The relationship between body fat mass and erectile dysfunction in Korean men: Hallym Aging Study / Int J Impot Res 21:179~186
Connelly JJ / 2006 / GATA2 is associated with familial early-onset coronary artery disease / PLoS Genet 2:e139
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