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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 725 - 735 (11page)
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Background Type 2 diabetes mellitus (T2DM) is associated with chronic hyperglycemia and lipid metabolism. A previous genome-wide association study revealed the TOMM40-APOE region as novel locus for T2DM susceptibility. Objective This association study was conducted to determine the genetic effects of APOE single nucleotide polymorphisms (SNPs) on T2DM susceptibility and lipid profiles in a Korean population. Methods A total of 6 tagging SNPs, including rs7412 and rs429358, were selected for ε genotype analysis and genotyped in 1436 subjects, consisting of 352 T2DM patients and 1084 unaffected controls. Results Logistic regression analyses were conducted and there were no significant associations among the APOE 6 tagging SNPs, ε genotypes, and haplotypes with T2DM susceptibility. To investigate the association of the APOE tagging SNPs with the lipid profiles, a regression analysis was conducted. As a result, rs7412 was significantly associated with the total cholesterol (TC) and low-density lipoprotein cholesterol (LDL) levels (Pcorr = 2.30 × 10–5 and 3.39 × 10–13, respectively) in the unaffected controls. The ε2 allele and ε3 allele were significantly associated with the TC (Pcorr = 4.46 × 10–6 and 0.02, respectively) and LDL levels (Pcorr = 3.54 × 10–14 and 0.0006, respectively) in the unaffected controls. Further analysis of only the unaffected controls was conducted. As a result, the APOE alleles ε2 and ε3 showed a significant association with the TC and LDL levels (P < 0.05). Conclusion The results of this study may help in understanding APOE polymorphisms and ε alleles and lipid profiles, which have been highly linked to T2DM, in a Korean population.
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참고문헌 (52)
참고문헌 신청
Afroze D / 2016 / ApoE gene polymorphism and its relationship with coronary artery disease in ethnic Kashmiri population / Clin Exp Med 16:551~556
Alharbi KK / 2014 / Association of apolipoprotein E polymorphism with type 2 diabetes mellitus in a Saudi population / DNA Cell Biol 33:637~641
Ali O / 2013 / Genetics of type 2 diabetes / World J Diabetes 4:114~123
Alvim RO / 2010 / APOE polymorphism is associated with lipid profle, but not with arterial stifness in the general population / Lipids Health Dis 9:128
Baars HF / 2011 / Clinical cardiogenetics / Springer
Alharbi KK / 2014 / Association of apolipoprotein E polymorphism with type 2 diabetes mellitus in a Saudi population / DNA Cell Biol 33:637~641
Ali O / 2013 / Genetics of type 2 diabetes / World J Diabetes 4:114~123
Alvim RO / 2010 / APOE polymorphism is associated with lipid profle, but not with arterial stifness in the general population / Lipids Health Dis 9:128
Baars HF / 2011 / Clinical cardiogenetics / Springer
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