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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 153 - 159 (7page)
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초록· 키워드
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SVA (SINE/VNTR/Alu) transposable element,one of non-LTR retrotransposons, emerged in the primategenome about 25 million years ago. Currently, *2,800SVA copies exist in the human genome. Recently, a groupof transposable elements named SVA2 is discovered.
SVA2 elements share the VNTR region with the SVAelement but do not contain the SINE-R region of the SVAelements. In this study, we studied the SVA2 evolution andthe impact of the SVA2 elements on primate genomes. Wefirst identified 144, 139, 136, 139, and 116 SVA2 elementsin the human, chimpanzee, gorilla, orangutan, and rhesusmacaque genomes, respectively. To examine the evolutionarystate and structure of the elements, we performedcomparative genomics, comparing human SVA2 with itsorthologous counterpart from non-human primates. Theresult suggests that SVA2 subfamily is not, at present,retrotranspositionally active in the primate genomesbecause none of the SVA2 elements identified in this studyare species-specific. In addition, we found that four humanSVA2 elements locate in human genes and two of themhave miRNA target sites, indicating that they might regulategene expression and involve in the gene-related humandiseases.
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참고문헌 (18)
참고문헌 신청
Batzer MA / 2002 / Alu repeats and human genomic diversity / Nat Rev Genet 3:370~379
Boeke JD / 1997 / LINEs and Alus—the polyA connection / Nat Genet 16:6~7
Callinan PA / 2006 / Retrotransposable elements and human disease / Genome Dyn 1:104~115
Christensen SM / 2005 / R2 target-primed reverse transcription: ordered cleavage and polymerization steps by protein subunits asymmetrically bound to the target DNA / Mol Cell Biol 25:6617~6628
Cost GJ / 2002 / Human L1 element target-primed reverse transcription in vitro / EMBO J 21:5899~5910
Boeke JD / 1997 / LINEs and Alus—the polyA connection / Nat Genet 16:6~7
Callinan PA / 2006 / Retrotransposable elements and human disease / Genome Dyn 1:104~115
Christensen SM / 2005 / R2 target-primed reverse transcription: ordered cleavage and polymerization steps by protein subunits asymmetrically bound to the target DNA / Mol Cell Biol 25:6617~6628
Cost GJ / 2002 / Human L1 element target-primed reverse transcription in vitro / EMBO J 21:5899~5910
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