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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,784 - 1,792 (9page)
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초록· 키워드
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The potential use of urinary nucleic acids as diagnostic markers in prostate cancer (PCa) was evaluated. Ninety-five urine samples and 234 prostate tissue samples from patients with PCa and benign prostatic hyperplasia (BPH) were analyzed. Micro-array analysis was used to identify candidate genes, which were verified by the two-gene expression ratio and validated in tissue mRNA and urinary nucleic acid cohorts. Real-time quantitative polymerase chain reaction (qPCR) was used to measure urinary nucleic acid levels and tissue mRNA expression. The TSPAN13-to-S100A9 ratio was selected to determine the diagnostic value of urinary nucleic acids in PCa (P = 0.037) and shown to be significantly higher in PCa than in BPH in the mRNA and nucleic acid cohort analyses (P < 0.001 and P = 0.013, respectively). Receiver operating characteristic (ROC) analysis showed that the area under the ROC curve was 0.898 and 0.676 in tissue mRNA cohort and urinary nucleic acid cohort, respectively. The TSPAN13-to-S100A9 ratio showed a strong potential as a diagnostic marker for PCa. The present results suggest that the analysis of urine supernatant can be used as a simple diagnostic method for PCa that can be adapted to the clinical setting in the future.
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참고문헌 (33)
참고문헌 신청
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정규원 / 2010 / Cancer Statistics in Korea: Incidence, Mortality and Survival in 2006-2007 / Journal of Korean Medical Science 25(8):1113~1121
Kyu-Won Jung / 2007 / Cancer Survival in Korea 1993-2002: A Population-Based Study / Journal of Korean Medical Science 22(S):5~10
Roobol MJ / 2007 / The value of different screening tests in predicting prostate biopsy outcome in screening for prostate cancer data from a multicenter study(ERSPC) / Prostate 67:439~446
Ralla B / 2014 / Nucleic acid-based biomarkers in body fluids of patients with urologic malignancies / Crit Rev Clin Lab Sci 51:200~231
정규원 / 2010 / Cancer Statistics in Korea: Incidence, Mortality and Survival in 2006-2007 / Journal of Korean Medical Science 25(8):1113~1121
Kyu-Won Jung / 2007 / Cancer Survival in Korea 1993-2002: A Population-Based Study / Journal of Korean Medical Science 22(S):5~10
Roobol MJ / 2007 / The value of different screening tests in predicting prostate biopsy outcome in screening for prostate cancer data from a multicenter study(ERSPC) / Prostate 67:439~446
Ralla B / 2014 / Nucleic acid-based biomarkers in body fluids of patients with urologic malignancies / Crit Rev Clin Lab Sci 51:200~231
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