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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 411 - 418 (8page)
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Purpose: The aim of this study was to identify a noninvasive urinary marker for prostate cancer (PCa) diagnosis and to validate the clinical performance of this novel urinary mRNA signature using the droplet digital polymerase chain reaction (ddPCR) approach. Materials and Methods: A gene expression microarray (HT-12, Illumina Inc., USA) was used to identify genes differentially expressed between 16 PCa and 8 benign prostatic hyperplasia (BPH) tissues; ddPCR (QX200; Bio-Rad Laboratories, USA) was carried out to quantify the expression of selected genes in urine. The urinary molecular PCa risk score (UMPCaRS) was calculated by using the sum of three upregulated genes as the numerator and the sum of three downregulated genes as the denominator. The diagnostic utility of the UMPCaRS was validated by using a screening set (10 PCa and 10 BPH samples) and a validation set (131 PCa and 105 BPH samples). Results: Three upregulated genes (PDLIM5, GDF-15, THBS4) and three downregulated genes (UPK1A, SSTR3, NPFFR2) were selected from the microarray and subjected to ddPCR. The UMPCaRS for PCa in the screening and validation sets was significantly higher than that for BPH. For the validation set, the diagnostic accuracy of the UMPCaRS was comparable with that of prostate-specific antigen (PSA). Importantly, in the “PSA gray zone” (3–10 ng/mL), the AUC for the UMPCaRS was 0.843 and that for PSA was 0.628 (p<0.001). Conclusions: The data demonstrate that the UMPCaRS is useful for discriminating between PCa and BPH in the “PSA gray zone”.
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참고문헌 (27)
참고문헌 신청
Hessels D / 2009 / The use of PCA3 in the diagnosis of prostate cancer / Nat Rev Urol 6:255~261
Brawer MK / 1999 / Prostate-specific antigen : current status / CA Cancer J Clin 49:264~281
Wolf AM / 2010 / American Cancer Society guideline for the early detection of prostate cancer: update 2010 / CA Cancer J Clin 60:70~98
Tosoian J / 2010 / PSA and beyond : the past, present, and future of investigative biomarkers for prostate cancer / Scientific-WorldJournal 10:1919~1931
Theodorescu D / 2008 / Discovery and validation of urinary biomarkers for prostate cancer / Proteomics Clin Appl 2:556~570
Brawer MK / 1999 / Prostate-specific antigen : current status / CA Cancer J Clin 49:264~281
Wolf AM / 2010 / American Cancer Society guideline for the early detection of prostate cancer: update 2010 / CA Cancer J Clin 60:70~98
Tosoian J / 2010 / PSA and beyond : the past, present, and future of investigative biomarkers for prostate cancer / Scientific-WorldJournal 10:1919~1931
Theodorescu D / 2008 / Discovery and validation of urinary biomarkers for prostate cancer / Proteomics Clin Appl 2:556~570
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