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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,101 - 1,109 (9page)
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Contribution of genetic predisposition to risk prediction of type 2 diabetes mellitus (T2DM) was investigated using a prospective study in middle-aged adults in Korea. From a community cohort of 6,257 subjects with 8 yr’ follow-up, genetic predisposition score with subsets of 3, 18, 36 selected single nucleotide polymorphisms (SNPs) (genetic predisposition score; GPS-3, GPS-18, GPS-36) in association with T2DM were determined, and their effect was evaluated using risk prediction models. Rs5215, rs10811661, and rs2237892 were in significant association with T2DM, and hazard ratios per risk allele score increase were 1.11 (95% confidence intervals: 1.06-1.17), 1.09 (1.01-1.05), 1.04 (1.02-1.07) with GPS-3, GPS-18, GPS-36, respectively. Changes in AUC upon addition of GPS were significant in simple and clinical models, but the significance disappeared in full clinical models with glycated hemoglobin (HbA1c). For net reclassification index (NRI), significant improvement observed in simple (range 5.1%-8.6%) and clinical (3.1%-4.4%) models were no longer significant in the full models. Influence of genetic predisposition in prediction ability of T2DM incidence was no longer significant when HbA1c was added in the models, confirming HbA1c as a strong predictor for T2DM risk. Also, the significant SNPs verified in our subjects warrant further research, e.g. gene-environmental interaction and epigenetic studies.
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참고문헌 (30)
참고문헌 신청
Zeggini E / 2008 / Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes / Nat Genet 40:638~645
Voight BF / 2010 / Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis / Nat Genet 42:579~589
Manolio TA / 2009 / Finding the missing heritability of complex diseases / Nature 461:747~753
Herder C / 2011 / Genetics of type 2 diabetes : pathophysiologic and clinical relevance / Eur J Clin Invest 41:679~692
Meigs JB / 2008 / Genotype score in addition to common risk factors for prediction of type 2 diabetes / N Engl J Med 359:2208~2219
Voight BF / 2010 / Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis / Nat Genet 42:579~589
Manolio TA / 2009 / Finding the missing heritability of complex diseases / Nature 461:747~753
Herder C / 2011 / Genetics of type 2 diabetes : pathophysiologic and clinical relevance / Eur J Clin Invest 41:679~692
Meigs JB / 2008 / Genotype score in addition to common risk factors for prediction of type 2 diabetes / N Engl J Med 359:2208~2219
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