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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 965 - 973 (9page)
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The purpose of this study was to investigate the utility of MRI findings after drug-eluting beads (DEB) - transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma in predicting time to progression (TTP). This study included 48 patients with 60 lesions who underwent liver MRI within 3 months after DEB-TACE. MRI was assessed for arterial enhancement pattern, late washout, arterioportal shunt, signal intensity on T2- weighted image, intratumoral septa, enhancing tissue on subtraction images, and treatment response. Cox-regression analysis was performed to identify independent factors to predict TTP. TTP was calculated using the Kaplan-Meier method with the log-rank test. Per lesion, 30 achieved complete remission, 22 had a partial response, and the remaining 8 lesions displayed stable disease on MRI. Arterial enhancement pattern, washout and enhancing tissue on subtraction images from MRI were associated with viable tumor on the last follow-up computerized tomography. Arterial enhancement, washout and enhancing tissue on subtraction images were significant predictors of TTP, but only enhancing tissue on subtraction images remained a significant predictor of TTP (P = 0.018) in the multivariate analysis. TTP was longer in the group without enhancing tissue on subtraction images compared to the group with enhancing tissue (601 days vs. 287 days, P < 0.001). Enhancing tissue on subtraction images from MRI after DEB-TACE is predictive for longer TTP
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참고문헌 (27)
참고문헌 신청
Kim KA / 2012 / Development of hepatocellular carcinomas in patients with absence of tumors on a prior ultrasound examination / Eur J Radiol 81:1450~1454
Lencioni R / 2012 / Chemoembolization for hepatocellular carcinoma / Semin Oncol 39:503~509
Pelletier G / 1990 / A randomized trial of hepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma / J Hepatol 11:181~184
Lin DY / 1988 / Hepatic arterial embolization in patients with unresectable hepatocellular carcinoma--a randomized controlled trial / Gastroenterology 94:453~456
Llovet JM / 2002 / Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma : a randomised controlled trial / Lancet 359:1734~1739
Lencioni R / 2012 / Chemoembolization for hepatocellular carcinoma / Semin Oncol 39:503~509
Pelletier G / 1990 / A randomized trial of hepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma / J Hepatol 11:181~184
Lin DY / 1988 / Hepatic arterial embolization in patients with unresectable hepatocellular carcinoma--a randomized controlled trial / Gastroenterology 94:453~456
Llovet JM / 2002 / Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma : a randomised controlled trial / Lancet 359:1734~1739
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