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Long-term Prognosis of Paroxysmal Atrial Fibrillation and Predictors for Progression to Persistent or Chronic Atrial Fibrillation in the Korean Population
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Long-term Prognosis of Paroxysmal Atrial Fibrillation and Predictors for Progression to Persistent or Chronic Atrial Fibrillation in the Korean Population

논문 기본 정보

자료유형
학술저널
저자정보
온영근 (성균관대학교)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.30 No.7 KCI Accredited Journals
발행연도
2015.1
수록면
895 - 902 (8page)

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표지
Long-term Prognosis of Paroxysmal Atrial Fibrillation and Predictors for Progression to Persistent or Chronic Atrial Fibrillation in the Korean Population
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Little is known about the long-term prognosis of or predictors for the different clinical types of atrial fibrillation (AF) in Korean populations. The aim of this study was to validate a risk stratification to assess the probability of AF progression from paroxysmal AF (PAF) to persistent AF (PeAF) or permanent AF. A total of 434 patients with PAF were consecutively enrolled (mean age; 71.7 ± 10.7 yr, 60.6% male). PeAF was defined as episodes that are sustained > 7 days and not self-terminating, while permanent AF was defined as an ongoing long-term episode. Atrial arrhythmia during follow-up was defined as atrial premature complex, atrial tachycardia, and atrial flutter. During a mean follow-up of 72.7 ± 58.3 months, 168 patients (38.7%) with PAF progressed to PeAF or permanent AF. The mean annual AF progression was 10.7% per year. In univariate analysis, age at diagnosis, body mass index, atrial arrhythmia during follow-up, left ventricular ejection fraction, concentric left ventricular hypertrophy, left atrial diameter (LAD), and severe mitral regurgitation (MR) were significantly associated with AF progression. In multivariate analysis, age at diagnosis (P = 0.009), atrial arrhythmia during follow-up (P = 0.015), LAD (P = 0.002) and MR grade (P = 0.026) were independent risk factors for AF progression. Patients with younger age at diagnosis, atrial arrhythmia during follow-up, larger left atrial chamber size, and severe MR grade are more likely to progress to PeAF or permanent AF, suggesting more intensive medical therapy with close clinical follow-up would be required in those patients.

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